Marimastat (BB 2516; TA2516) is a broad spectrum inhibitor of MMPs (IC50 values are 3, 5, 6, 9 and 13nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively).
信号通路
Metabolism; Proteases
靶点
MMP-9
MMP-1
MMP-2
MMP-14
MMP-7
IC50
3nM
5nM
6nM
9nM
13nM
体外研究
Marimastat early downregulated the expression of Notch target genes, such as Hes1 and Hes5. MMP-2 and MMP-9 profiling on proliferating and differentiating NPs.
体内研究
The marimastat was administered at a dose of 8.7mg/kg/day over a 14-day period via a subcutaneous osmotic pump. The control group received vehicle only via a subcutaneous osmotic pump.Chemoradiation + marimastat therapy had delayed tumor growth, compared to the chemoradiation alone.
临床实验
N/A
特征
N/A
相关实验数据(此数据来自于公开文献,信裕生物并不保证其有效性):
酶活性检测实验
方法
N/A
细胞实验
细胞系
N/A
浓度
N/A
处理时间
N/A
方法
N/A
动物实验
动物模型
N/A
配制
N/A
剂量
N/A
给药方式
N/A
参考文献: 1. Rasmussen HS, et al. Pharmacol Ther. 1997, 75(1), 69-75.
2. Sinno M, et al. Stem Cells Dev. 2013 Feb 1, 22(3), 345-58.
3. Skipper JB, et al. ORL J Otorhinolaryngol Relat Spec. 2009, 71(1), 1-5.
包装清单: