CINPA1,102636-74-8

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CINPA1

CAS No. : 102636-74-8

MCE 国际站：CINPA1

产品活性：CINPA1是一种不激活孕烷 X 受体 (PXR) 的，强效、特异性的组成型雄甾烷 (CAR) 抑制剂。CINPA1 能下调 CAR 介导的转录，IC₅₀ 值为 ~70 nM。CINPA1 可以作为 CAR 功能研究的分子工具。

研究领域：Others

作用靶点：Others

In Vitro: CINPA1 (1μM ; 24 hours) inhibits CAR-mediated transactivation without activating PXR in HepG2 cells.
?CINPA1 is a specific xenobiotic receptor inhibitor.
?CINPA1 inhibits CAR-mediated gene expression in primary human hepatocytes, where CAR is endogenously expressed.
?CINPA1 does not alter the protein levels or subcellular localization of CAR.
?CINPA1 increases corepressor and reduces coactivator interaction with the CAR ligand-binding domain in mammalian two-hybrid assays.
?CINPA1 disrupts CAR binding to the promoter regions of target genes in chromatin immunoprecipitation assays.
?CINPA1 efficiently inhibits CAR-LBD interaction with the coactivator peptide that suggesting that CINPA1 is a ligand of CAR.

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