CKI-7,120615-25-0

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CKI-7 free base

CAS No. : 120615-25-0

MCE 国际站：CKI-7 free base

产品活性：CKI-7 free base 是一种有效且 ATP 竞争性的酪蛋白激酶 1 (CK1) 抑制剂，IC₅₀ 为 6 μM，K_i 为 8.5 μM。CKI-7 free base 选择性抑制 Cdc7 激酶，还抑制 SGK，S6K1 以及 MSK1。CKI-7 free base 对酪蛋白激酶 II 和其他蛋白激酶的作用弱得多。

研究领域：Cell Cycle/DNA Damage  |  Stem Cell/Wnt  |  Metabolic Enzyme/Protease  |  MAPK/ERK Pathway

作用靶点：Casein Kinase  |  CDK  |  SGK  |  Ribosomal S6 Kinase (RSK)

In Vitro: CKI-7 (0.1-10 μM; 5 days; ES cells) treatment significantly increases the expression of the early neuroectodermal marker Sox1 and the number of cells positive for the neural markers nestin and βIII-tubulin, in a concentration-dependent manner.
CKI-7 (5 μM; 5 days; ES cells) treatment suppresses SFEB-induced β-catenin stabilization on day 5, indicating that CKI-7 inhibits Wnt signaling.

In Vivo: In vivo dose-dependent anti-tumor activity of CKI-7 is demonstrated in a SCID-Beige mouse systemic tumor model utilzing a recently isolated Philadelphia chromosome positive acute lymphoblastic leukemia cell line. Standard cell cycle synchronization studies established that exposure to CKI-7 results in cell cycle dependent caspase 3 activation and apoptotic cell death.

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