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- 详细信息
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
LSN3106729 hydrochloride
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2704316-82-3
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥4090.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1590.0 |
| 规格： | 5 mg | 产品价格： | ￥3500.0 |
| 规格： | 10 mg | 产品价格： | ￥5500.0 |
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Abemaciclib metabolite M18 hydrochloride
CAS No. : 2704316-82-3
MCE 国际站：Abemaciclib metabolite M18 hydrochloride
产品活性：Abemaciclib metabolite M18 (LSN3106729) hydrochloride，Abemaciclib (HY-16297A) 的代谢物，是一种具有抗肿瘤活性的 CDK 抑制剂。Abemaciclib metabolite M18 hydrochloride 和 CRBN 配体可用于设计 PROTAC CDK4/6 降解剂。
研究领域：PROTAC | Cell Cycle/DNA Damage
作用靶点：Ligands for Target Protein for PROTAC | CDK
In Vitro: Abemaciclib metabolite M18 hydrochloride exhibits T1/2 of 43.1 hr in plasma in healthy subjects.
?CDK4/6 inhibitors’ chief mechanism of action is inhibition of retinoblastoma (RB) protein phosphorylation and thus the induction of cell cycle arrest, CDK4/6 inhibitors alter cancer cell biology in other ways.
In Vivo: CDK4/6 inhibitors results T-cell persistence and immunologic memory increasing in mice receiving tumor-specific CD8+ T cells.
相关产品：Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Kinase Inhibitor Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Target Protein Ligand Library | Cancer Stem Cells Compound Library | Membrane Protein-targeted Compound Library | Serine/Threonine Kinase Inhibitor Library | Palbociclib | (+)-JQ-1 | Ibrutinib | Abemaciclib | Ro-3306 | Ribociclib | Dinaciclib | GSK3326595 | Quizartinib | THZ1 | Flavopiridol | SR-4835 | (R)-Roscovitine | THZ531 | AZD4573 | SY-5609 | Kenpaullone | Wogonin | SNS-032 | GSK 3 Inhibitor IX | Cirtuvivint | NVP-2 | Toyocamycin | Fadraciclib | Simurosertib | AT7519 | OTS964 hydrochloride
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
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