CLK-IN-T3,2109805-56-1

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CLK-IN-T3

CAS No. : 2109805-56-1

MCE 国际站：CLK-IN-T3

产品活性：CLK-IN-T3 是一种高效，选择性和稳定的 CDC 样激酶 (CLK) 抑制剂，对 CLK1，CLK2 和 CLK3 蛋白激酶的 IC₅₀ 分别为 0.67 nM，15 nM 和 110 nM。CLK-IN-T3 具有抗癌活性。

研究领域：Cell Cycle/DNA Damage  |  Protein Tyrosine Kinase/RTK

作用靶点：CDK  |  DYRK

In Vitro: CLK-IN-T3 inhibits DYRK1A (IC₅₀=260 nM) and DYRK1B (IC₅₀=230 nM).
CLK-IN-T3 (0.1-10.0 µM; 24 hours) results in mild cell cycle arrest at the G2/M boundary with long-duration (24 h).
CLK-IN-T3 (0.5-1.0 µM; 6 hours) decreases phosphorylation of CLK-targeted SR proteins and CLK proteins increase slightly.

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