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- 详细信息
- 技术资料
- 保存条件：
-20°C, sealed storage, away from moisture and light
- 英文名：
Hyperforin DCHA
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
238074-03-8
- 规格：
500 μg/1 mg/5 mg
| 规格： | 500 μg | 产品价格： | ￥800.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1200.0 |
| 规格： | 5 mg | 产品价格： | ￥4200.0 |
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Hyperforin dicyclohexylammonium salt
CAS No. : 238074-03-8
MCE 国际站：Hyperforin dicyclohexylammonium salt
产品活性：贯叶金丝桃素二环己基铵盐 (Hyperforin DCHA) 是瞬时受体典型 6 (TRPC6) 通道激活剂。Hyperforin dicyclohexylammonium salt 通过激活 Ca2+ 传导非选择性典型 TRPC6 通道来调节 Ca2+ 水平。Hyperforin dicyclohexylammonium salt 还表现出多种药理活性，包括抗抑郁、抗肿瘤、抗痴呆、抗糖尿病等。Hyperforin dicyclohexylammonium salt 调节 γδ T 细胞分泌 IL-17α，改善Imiquimod (HY-B0180) 诱导的银屑病样小鼠皮肤炎症。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：TRP Channel | Calcium Channel
In Vitro: Hyperforin dicyclohexylammonium salt has a multi-directional mechanism of action. It blocks conductance of ligand-gated (GABA, NMDA, and AMPA receptors) and voltage-gated channels (Ca2+, K+, and Na+).
Hyperforin dicyclohexylammonium salt (0.1, 1, 10 μM; 2 h) reduces the expression and secretion of IL-17A in γδ T cell in vitro cultured murine splenic γδ T cells.
Hyperforin dicyclohexylammonium salt (0.1, 1, 10 μM; 2 h) suppresses phosphorylation of MAPK and STAT3 pathways in TNF-α stimulated HaCaT cells.
Hyperforin dicyclohexylammonium salt (IC50=3.7 μmol/L) inhibits the microvascular tube formation and proliferation of HDMEC in a dose-dependent manner without toxic effects.
In Vivo: Hyperforin dicyclohexylammonium salt (5 mg/kg; i.p.; once daily for 7 d) ameliorates Imiquimod (HY-B0180)-induced psoriatic skin lesion in mice, as well as inhibiting inflammatory cell infiltration and inflammatory cytokines release.
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