Reslizumab瑞利珠单抗瑞利珠单抗,241473-69

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Reslizumab

CAS No. : 241473-69-8

MCE 国际站：Reslizumab

产品活性：Reslizumab (Sch 55700) 是靶向人白介素 5 (IL-5) 的人源化单克隆抗体，用于研究嗜酸性粒细胞性哮喘。Reslizumab 可有效阻断 IL-5 的功能。Reslizumab 对人 IL-5 具有高结合亲和力，在 Biacore 表面等离振子共振和动力学排斥分析中，K_D 值分别为 109 pM 和 4.3 pM。

研究领域：Immunology/Inflammation

作用靶点：Interleukin Related

In Vitro: Reslizumab (Sch 55700) (0-10 nM, 48 h) inhibits IL-5-dependent cell proliferation, with an IC₅₀ value of approximately 91.1pM.

In Vivo: Reslizumab (Sch 55700) (0-10 mg/kg; i.p. or i.m.) inhibits pulmonary eosinophilia in a dose-dependent manner in allergic mice.
Reslizumab (0.03-30 mg/kg; i.p.) inhibits both the pulmonary eosinophilia and airway hyperresponsiveness, and at 30 mg/kg, i.p. inhibits allergic, but not histamine-induced bronchoconstriction in allergic guinea pigs.
Reslizumab (0.1-1 mg/kg; i.p.) blocks the pulmonary eosinophilia and neutrophilia caused by tracheal injection of hIL-5 in guinea pigs.
Reslizumab (0.3 mg/kg; i.v.) blocks the pulmonary eosinophilia caused by antigen challenge for up to six months in allergic cynomolgus monkeys.

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