U-46619,56985-40-1

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U-46619

CAS No. : 56985-40-1

MCE 国际站：U-46619

产品活性：U-46619 (9,11-Methanoepoxy PGH2) 是一种稳定的 Thromboxane A2 (HY-113350) (TXA2) 的类似物，可作为有效的 TXA2 (TP) 激动剂。 U-46619 也是一种 RhoA 激动剂。 U-46619 通过 TXA2 受体激活来刺激 RhoA 的激活。

研究领域：GPCR/G Protein

作用靶点：Prostaglandin Receptor

In Vitro: U-46619 (1 nM-10 μM) causes platelets shape change and aggregation in a concentration-dependent manner, and with EC₅₀s of 0.58 μM and 0.013 μM for aggregation and shape change, respectively.
?U-46619 (10 nM-10 μM) increases internal Ca²⁺ concentration ([Ca²⁺]i) and activates phosphoinositide (PI) hydrolysis in a concentration-dependent manner with a similar concentration-dependency.
?U-46619 (3 nM-10 μM) also activates GTPase concentration-dependently in the membranes derived from platelets.
?U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways.

In Vivo: U-46619 (5 μg/kg; i.v.) increases blood pressure in male spontaneously hypertensive rats (SHR).

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