BCI-215,1245792-67-9

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BCI-215

CAS No. : 1245792-67-9

MCE 国际站：BCI-215

产品活性：BCI-215 是一种高效、肿瘤细胞选择性的双重特异性磷酸酶 DUSP-MKP 抑制剂。BCI-215 对肿瘤细胞有细胞毒性，但对正常细胞无毒性。

研究领域：Metabolic Enzyme/Protease

作用靶点：Phosphatase

In Vitro: BCI-215 concentration-dependently increases pERK levels in DUSP-overexpressing cells with IC₅₀ value in the micromolar range.
BCI-215 (1-20 μM; 6 hours) retains fibroblast growth factor hyperactivating and cellular DUSP6/MKP-3 and DUSP1/MKP-1 inhibitory activity but is nontoxic to zebrafish embryos and an endothelial cell line.
BCI-215 inhibits survival and motility of MDA-MB-231 human breast cancer cells but does not affect viability of cultured hepatocytes.
BCI-215 is completely devoid of hepatocyte toxicity up to 100 µM.
BCI-215 does not generate ROS in hepatocytes or in developing Zebrafish larvae.BCI-215 (22 µM) has antimigratory and proapoptotic activities in breast cancer cells that correlate with induction of ERK phosphorylation.
BCI-215 (20 µM; 1 hour) induces mitogenic and stress signaling in cancer cells without generating ROS.

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