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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
NIBR3049
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1260181-14-3
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2085.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥550.0 |
| 规格： | 5 mg | 产品价格： | ￥1800.0 |
| 规格： | 10 mg | 产品价格： | ￥2900.0 |
| 规格： | 25 mg | 产品价格： | ￥6000.0 |
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TCS 21311
CAS No. : 1260181-14-3
MCE 国际站：TCS 21311
产品活性：TCS 21311 (NIBR3049) 是一种有效的高选择性 JAK3 抑制剂，其 IC50 为 8 nM，它的选择性是 JAK1，JAK2 和 TYK2 的100倍以上。TCS 21311 (NIBR3049) 抑制 PKCα，PKCθ 和 GSK3β，IC50 值分别为 13、68 和 3 nM。
研究领域：Epigenetics | Protein Tyrosine Kinase/RTK | JAK/STAT Signaling | Stem Cell/Wnt | TGF-beta/Smad | PI3K/Akt/mTOR
In Vitro: TCS 21311 (NIBR3049) exhibits IC50 values of 1.017, 2.550 and 8.055 μM for JAK1, JAK2 and TYK2, respectively in a enzymatic Jak assay.
TCS 21311 (NIBR3049) shows moderate activity in this cellular assay (IC50=689 nM, Jurkat cells), which is in good agreement with its enzymatic Pkc activity.
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