- ¥646
- 碧云天（beyotime）
- P6191-5μg
- 2025年08月27日
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- 详细信息
- 技术资料
- 规格：
5μg
| Species | Gene ID | Accession | Source | Length | MW | Tag |
| Mouse | 18121 | P97466 | E. coli | 206aa | 46.4kDa | － |
| About this Antibody | |
| Name | Recombinant Murine Noggin (Recombinant Murine Noggin; rMuNoggin)；Recombinant Mouse Noggin ; 重组小鼠生长因子 |
| Synonyms | NOG; SYM1; SYNS1; noggin; SYM1; symphalangism 1 (proximal); synostoses (multiple) syndrome 1; SYNS1 |
| Purity | >95% by SDS-PAGE and HPLC analyses. |
| Biological Activity | Fully biologically active when compared to standard. The ED50 as determined by inhibiting BMP-4-induced alkaline phosphatase production of murine ATDC5 cells is less than 2ng/ml, corresponding to a specific activity of >5.0×105IU/mg in the presence of 5ng/ml BMP-4. |
| Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation | Lyophilized from a 0.2μM filtered concentrated solution in 30% acetonitrile, 0.1% TFA. |
| Endotoxin | Less than 1EU/μg of rMuNoggin as determined by LAL method. |
| Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 10mM HAc to a concentration less than 0.25mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions. |
| Category | Cytokine |
| Background | Noggin encoded by the NOG gene, was first isolated from Xenopus, having the function of inducing secondary axis formation in frog embryos. It inhibits TGF-β family ligands and preventing them from binding to their corresponding receptors. Noggin was originally found as a BMP-4 antagonist, and then has been shown to modulate the activities of other BMPs (BMP-2, 7, 13 and 14). Additionally, it has pleiotropic effect, both in early development and later stages. The results of the mouse knockout of noggin suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. In recent report, proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have relation with the mutant of evolutionarily conserved amino acid residues of Noggin. Mature mouse Noggin shares 99% and 83%a.a. sequence identity with human and Xenopus Noggin, respectively. |
| Amino Acid Sequence | MQHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGPAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC |
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Recombinant Murine Noggin
¥646
