重组小鼠IL-11北京现货

特别提示：包括重组小鼠IL-11在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组小鼠IL-11
英文名称：Recombinant Murine Interleukin-11
产品货号：GS4477
产品规格：2μg

分子量：Approximately 19.1kDa,a single non-glycosylated polypeptide chain containing 179 amino acids.
储存条件：冷冻（-20℃）

概述

Interleukin-11(IL-11)is encoded by the IL11 gene.IL-11 is a multifunctional cytokine first isolated from bone marrow-derived stromal cells.IL-11 receptor activation requires formation of a complex of two IL-11 molecules with two molecules of the ligand-binding IL-11 Rα subunit and two molecules of the expressed cell signaling β subunit,gp130.IL-11 is a member of the IL-6 superfamily,distinguished based on their use of the common co-receptor gp130.IL-11 can directly stimulate the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells,and induce megakaryocyte maturation resulting in increased platelet production.Mature murine IL-11 shares 88%amino acid sequence identity with human IL-11.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞97%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using murine T11 cells is less than 2ng/ml,corresponding to a specific activity of>5.0×105 IU/mg.
成分	Lyophilized from a 0.2μmfiltered solution in PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rMuIL-11 as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	MPGPPAGSPR VSSDPRADLD SAVLLTRSLL ADTRQLAAQM RDKFPADGDHSLDSLPTLAM SAGTLGSLQL PGVLTRLRVD LMSYLRHVQW LRRAGGPSLKTLEPELGALQ ARLERLLRRL QLLMSRLALP QAAPDQPVIP LGPPASAWGSIRAAHAILGG LHLTLDWAVR GLLLLKTRL

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