- ￥5832.53
- nsjbio
- V7121SAF-100UG
- 2025年11月26日
- Mouse
- Human. Other species not tested.
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- 文献和实验
- 技术资料
- 免疫原：
Recombinant full-length human KRT14 protein was used as the immunogen for the Keratin 14 antibody.
- 亚型：
Mouse IgG3
- 克隆性：
单克隆
- 适应物种：
Human. Other species not tested.
- 宿主：
Mouse
- 规格：
100 ug
Primary antibody
纯化方法：
Purified
通用信息：
1 mg/ml in 1X PBS; BSA free, sodium azide free
产品描述：
Cytokeratin 14 (CK14) belongs to the type I (or A or acidic) subfamily of low molecular weight keratins and exists in combination with keratin 5 (type II or B or basic). CK14 is found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells. Anti-CK14 is useful in differentiating squamous cell carcinomas from poorly differentiated epithelial tumors. Anti-CK14 is one of the specific basal markers for distinguishing between basal and non-basal subtypes of breast carcinomas. Anti-CK14 is also a good marker for differentiation of intraductal from invasive salivary duct carcinoma by the positive staining of basal cells surrounding the in-situ neoplasm as well as for differentiation of benign prostate from prostate carcinoma. Furthermore, this antibody has been useful in separating oncocytic tumors of the kidney from its renal mimics, and in identifying metaplastic carcinomas of the breast.
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文献和实验Structure and Properties of Human Immunoglobulin Light-Chain Dimers
Antibodies are multisubunit proteins, but unlike many other multisubunit proteins, it is possible to study structural and functional properties of an antibody subunit free of the others. Thus, antibodies are singular proteins
Antibody Affinity Maturation by Chain Shuffling
Phage display can be used to increase the affinity of antibodies more than 1,000-fold (1 ,2 ). The starting point is typically a specific antibody isolated from a phage antibody library (see Chapter 8 ). To accomplish affinity maturation
Crystallographic and Chromatographic Methods for Study of Antibody Light Chains and Other Proteins
A three-dimensional structure of reasonably high resolution is the starting point of any protein engineering project, whether intended to improve the affinity of an antibody, change the specificity of an enzyme, or to test a hypothesis
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