Recombinant full-length human protein was used as the immunogen for the recombinant PLAP antibody.
亚型:
Rabbit IgG, kappa
克隆性:
单克隆
适应物种:
Human. Other species not known.
宿主:
Rabbit
规格:
100 ug
产品类型:
Primary antibody
纯化方法:
Purified
通用信息:
1 mg/ml in 1X PBS; BSA free, sodium azide free
产品描述:
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
联系方式: