A recombinant protein corresponding to the intracellular domain of human Desmoglein 1 was used as the immunogen for the DSG1 antibody.
亚型:
Mouse IgG1, kappa
克隆性:
单克隆
适应物种:
Human. Other species not known.
宿主:
Mouse
规格:
100 ug
产品类型:
Primary antibody
纯化方法:
Purified
通用信息:
1 mg/ml in 1X PBS; BSA free, sodium azide free
产品描述:
Desmoglein 1 (DSG1) is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.
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