Stimulated human leukocytes were used as the immunogen for the LCA antibody.
亚型:
Mouse IgG1, kappa
克隆性:
单克隆
适应物种:
Human. Other species not known.
宿主:
Mouse
规格:
100 ug
产品类型:
Primary antibody
纯化方法:
Purified
通用信息:
1 mg/ml in 1X PBS; BSA free, sodium azide free
产品描述:
CD45R, also designated CD45, B220, LCA and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.
Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. This antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms. 联系方式: