A human cell nuclear fraction was used as the immunogen for this Ku70 + Ku80 antibody.
亚型:
Mouse IgG1, kappa
克隆性:
单克隆
适应物种:
Human
宿主:
Mouse
规格:
20 ug
产品类型:
Primary antibody
纯化方法:
Purified
通用信息:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
产品描述:
Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V(D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system. In addition to its role in NHEJ, Ku is also required for telomere length maintenance and subtelomeric gene silencing. Ku was originally identified when patients with systemic lupus erythematosus were found to have high levels of autoantibodies to the protein. [Wiki]
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