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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
TLR7 agonist T7
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1062444-54-5
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥791.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥300.0 |
| 规格： | 5 mg | 产品价格： | ￥1000.0 |
| 规格： | 10 mg | 产品价格： | ￥1600.0 |
| 规格： | 25 mg | 产品价格： | ￥3300.0 |
| 规格： | 50 mg | 产品价格： | ￥4800.0 |
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1V209
CAS No. : 1062444-54-5
MCE 国际站：1V209
产品活性：1V209 (TLR7 agonist T7) 是 Toll-like receptor 7 (TLR7) 激动剂，具有抗肿瘤作用。1V209 可与各种多糖缀合，以改善其水溶性，增强功效并保持低毒性。
作用靶点：Toll-like Receptor (TLR)
In Vitro: 1V209 (0.1-10 μM) treatment significantly stimulates TNFα production in RAW246.7 cells.
1V209 (18 hours) treatment increases IL-6 production comparain bone marrow derived dendritic cells.
In Vivo: The intravenous (IV) administration of the formulation to mice bearing 4T1 breast cancer tumors results in nanoparticle accumulation in tumors, reduction in primary tumor growth, and inhibition of lung metastases, as compared to saline-treated animals. Mice administered 1V209 experience significantly increases plasma levels of proinflammatory cytokines IL-6, IP-10, and MCP-1 at 2 h following IV administration.
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文献和实验0.93(2.30-6.90)10.1±1.119.50±1.10(5.60-12.1)2.52±0.243.20±0.22(2.00-5.40)地鼠0.42±0.120.36±0.11(0.20-0.74)54.8±11.951.5±11.0(10.0-80.0)1.05±0.280.98±0.30(0.35-1.65)73.4±12.665.0±10.5(32.6-118)23.4±6.7420.8±5.64(12.5-26.0)4.85±0.454.36±0.50(1.80-5.30)128±
. Buffer Mw pKa 20o C Working range delta pKa per 10o C MES 2-(N -morpholino)ethanesulfonic acid 195.2 6.15 5.5-6.7 -0.110 Bis-Tris bis (2-hydroxyethyl)iminotris (hydroxymethyl)methane 209.2 6.5 5.8-7.2 ADA N -(2-acetamido
（76.0） 50 （54.0） 16 （37.3） 209 209 X2=29.76 n=4 P 括号内数字为理论分布数 实习表17-12
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