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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1059070-10-8
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1430.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥495.0 |
| 规格： | 5 mg | 产品价格： | ￥1300.0 |
| 规格： | 10 mg | 产品价格： | ￥2200.0 |
| 规格： | 25 mg | 产品价格： | ￥4400.0 |
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DSR-6434
CAS No. : 1059070-10-8
MCE 国际站：DSR-6434
产品活性：DSR-6434 是一种有效的选择性的 Toll 样受体 7 (TLR7) 激动剂，对人和小鼠 TLR7 的 EC50 分别为 7.2 nM 和 4.6 nM。DSR-6434 具有很强的抗肿瘤作用。
作用靶点：Toll-like Receptor (TLR)
In Vitro: To assess the specificity of DSR-6434 toward TLR7, an NF-κB-driven reporter assay is performed in HEK293 cells engineered to express either hTLR7, TLR8 or TLR9. In this assay, successful binding of DSR-6434 to the specific receptor leads to NF-κB activation. DSR-6434 is capable of stimulating reporter gene activity only in HEK293 cells expressing hTLR7 and not in HEK293 cells expressing the structurally similar hTLR8 or hTLR9.
In Vivo: DSR-6434 treatment (Compound 20; 0.1-1 mg/kg; intravenous injection; biweekly; for 4 weeks; B6C3F1 mice) suppresses the lung metastasis significantly, 78% inhibition at 0.1 mg/kg dosing (with no tumor metastasis at the 1 mg/kg group).
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文献和实验。 列如：在低温冷库中，一般是-25摄氏度的环境温度，必须使用带外接探头的DSR-THEXT型号的温湿度记录仪进行监控，具体参数为： 温度范围 –40 ℃~ 85 ℃ 温度精度 ±0.3 ℃ 温度分辨率 0.1 ℃/°F 湿度范围 0%~100% RH 湿度精度 ±3%RH(10 ％～ 85 ％ ) ，其他范围 ±5 ％ ( 测试环境 23 ℃ ~±2 ℃ ) 湿度分辨率 0.1% RH Zoglab佐格DSR温湿度监控
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Sequencing gel concentrate solution: 25% 19:1 acrylamide/bisacrylamide/8.3 M urea Sequencing gel buffer concentrate: 8.3 M urea/10× TBE
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