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- 2025年12月05日
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2749492-84-8
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K-Ras ligand-Linker Conjugate 1
CAS No. : 2749492-84-8
MCE 国际站：K-Ras ligand-Linker Conjugate 1
产品活性：K-Ras ligand-Linker Conjugate 1 包含靶蛋白 K-Ras 配体和 PROTAC linker，可募集 E3 连接酶 (如 VHL，CRBN，MDM2 和 IAP 等类型)。K-Ras ligand-Linker Conjugate 1 可用于合成 PROTAC K-Ras Degrader-1 (HY-129523)，PROTAC K-Ras Degrader-1 是一种有效的 PROTAC K-Ras 降解剂，在 SW1573 中对 K-Ras 的降解率 ≥70%。
研究领域：PROTAC
作用靶点：Target Protein Ligand-Linker Conjugates
In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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文献和实验AntibodyDrug Conjugate (ADC) Clinical Pipeline: A Review
game, requiring thoughtful combination of antibody, linker, and drugs in the context of a target and a defined cancer indication. Lessons learned from the first-generation antibody–drug conjugate (ADC) and improvement of the technology guided the design
In Vivo Testing of Drug-Linker Stability
drug release in circulation and efficiently converted into active drugs in the tumor tissues. Designing the right combination of monoclonal antibody (mAb), linker and drug, requires monitoring and understanding the behavior of all three components
Direct Attachment of Conjugate Groups to the 5′ Terminus of Oligodeoxyribonucleotides
protocols for the attachment of intercalating and photoreactive conjugate groups to oligodeoxyribonucleotides. Protocols are given for acridine? and psoralen?conjugated oligonucleotides, and include attachment of the linker, preparation
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