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PF-06446846 hyd
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4°C, sealed storage, away from moisture
货期:1-2天
MedChemExpress LLC
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
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CAS No. : 1632250-50-0
MCE 国际站:PF-06446846 hydrochloride
产品活性:PF-06446846 hydrochloride 是一种具有口服活性,高选择性前蛋白转化酶枯草杆菌蛋白酶/kexin 9 型 (PCSK9) 的翻译抑制剂。PF-06446846 hydrochloride 可通过诱导核糖体停在密码子 34 周围,从而抑制 PCSK9。
研究领域:Metabolic Enzyme/Protease
作用靶点:Ser/Thr Protease
In Vitro: PF-06446846 inhibits the secretion of PCSK9 by Huh7 cells with an IC50 of 0.3 μM.
In Vivo: PF-06446846 (oral gavage; 5-50 mg/kg/day for 14 days) lowers plasma PCSK9 in a dose-dependent manner and lowers total cholesterol levels.
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