重组人IL-17B北京现货

特别提示：包括重组人IL-17B在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人IL-17B
英文名称：Recombinant Human Interleukin-17B
产品货号：GS4856
产品规格：5μg

分子量：Approximately 36.5kDa,a non-disulfide-linked homodimer of two 161 amino acid polypeptide chains.
储存条件：冷冻（-20℃）

概述

The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus.IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation.IL-17 is induced by IL-15 and IL-23,mainly in activated CD4+ T cells distinct from Th1 or Th2 cells.IL-17F is the most homologous to IL-17,but is induced only by IL-23 in activated monocytes.IL-17B binds the IL-17B receptor,but not the IL-17 receptor;it is most homologous with IL-17D,which is expressed by resting CD4+ T cells and CD19+ B cells.IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue.IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞95%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by inducing IL-8 secretion of human HepG2 cells is less than 1.0μg/ml,corresponding to a specific activity of>1000 IU/mg.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4,with 0.1%Tween-20 and 3%Trehalose.
内毒素	Less than 0.1 EU/μg of rHuIL-17B as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	MQPRSPKSKR KGQGRPGPLA PGPHQVPLDL VSRMKPYARM EEYERNIEEM VAQLRNSSEL AQRKCEVNLQ LWMSNKRSLS PWGYSINHDP SRIPVDLPEA RCLCLGCVNP FTMQEDRSMV SVPVFSQVPV RRRLCPPPPR TGPCRQRAVM ETIAVGCTCI F

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