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CD45RO (T-Cell Marker) Antibo

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  • $495
  • Leading Biology
  • 2025年10月08日
  • IHC, IF, FC
  • Mouse
  • Human, Marmoset, Chimpanzee
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 亚型

      Mouse / IgG2a, kappa

    • 保存条件

      Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

    • 克隆性

      单克隆

    • 适应物种

      Human, Marmoset, Chimpanzee

    • 库存

      100

    • 宿主

      Mouse

    • 应用范围

      IHC, IF, FC

    • 规格

      7 ml

    Prouduct: We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CD45RO (T-Cell Marker) Antibody. Functiong: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). Summary: Recognizes a 180-185kDa protein, identified as isoform of leukocyte common antigen (CD45RO) (4th Leucocyte Typing Workshop: Code No. N31). The epitope recognized by this antibody is sensitive to neuraminidase digestion. This antibody reacts with mature activated T-cells, most thymocytes, and a sub-population of resting T-cells within both CD4 and CD8 subsets. It shows no reactivity with normal B or natural killer cells, but reacts with granulocytes and monocytes. Reportedly, it is useful to identify T-cell lymphomas and leukemias. It rarely stains NK cells or B-cell lymphomas.

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    图标文献和实验
    相关实验
    • Bifunctional Antibody Fragment-Based Fusion Proteins for the Targeted Elimination of Pathogenic T-Cell Subsets

      cell death (AICD). Recently, we demonstrated that a recombinant fusion protein comprising a T-cell-targeted anti-CD7 scFv antibody fragment genetically fused to soluble FasL (sFasL) can eliminate synovial fluid T cells in the absence of activity

    • Identification of T-Cell Epitopes

      , which secrete γ-interferon, resulting in macrophage activation, or TH2 cells, which secrete interleukin-4 (IL4), resulting in B-cell differentiation and antibody secretion (7 , 8 ). Experiments on T-cells recognizing Leishmania antigens were important

    • Human T cell activation

      ) should be performed for optimization. Add 100l of the cell suspension to each well. For each condition, use triplicate wells. Add soluble antibody in 100l to each well. Titrate antibodies for optimal performance in the assay conditions used. If isolated T

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