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- ￥1375 - 5000
- Leading Biology
- ApR04912G
- 美国
- 2025年10月05日
- WB
- Rabbit
- H
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- 文献和实验
- 技术资料
- 靶点：
Bone morphogenetic protein 4, BMP-4, Bone morphogenetic protein 2B, BMP-2B, BMP4, BMP2B, DVR4
- 浓度：
Affinity Purification
- 应用范围：
WB
- 宿主：
Rabbit
- 适应物种：
H
- 保质期：
1-2年
- 供应商：
安诺伦（北京）生物科技有限公司
- 克隆性：
Polyclonal
- 保存条件：
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 免疫原：
This BMP4 antibody is generated from a rabbit immunized with a recombinant protein of human BMP4.
- 规格：
400 µl/200 µl/100 µl/50 µl
| 规格： | 400 µl | 产品价格： | ￥5000.0 |
|---|---|---|---|
| 规格： | 200 µl | 产品价格： | ￥3250.0 |
| 规格： | 100 µl | 产品价格： | ￥2250.0 |
| 规格： | 50 µl | 产品价格： | ￥1375.0 |
细胞定位：Secreted, extracellular space, extracellular matrix
功能：Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis (PubMed:31363885). Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:25868050, PubMed:8006002). Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:25868050, PubMed:29212066). Can also signal through non- canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades (PubMed:31363885). For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response (PubMed:31363885).
总结：Tissue Location: Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines
稀释方法：WB--1:1000-1:2000
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文献和实验Human Embryonic Stem Cell Derivation, Maintenance, and Differentiation to Trophoblast
introduces some basic and widely recognized methods that we use in our hESC core laboratory. Specifically, it includes methods for (1) deriving hESC lines without using enzyme and antibody to isolate the inner cell mass; (2) sustaining hESC self-renewal
Interaction Trap/Two‐Hybrid System to Identify Interacting Proteins
of interest Plasmids (see Table 4.4.1 ): e.g., pEG202 (Fig. ), pSH18‐34 (Fig. ), pSH17‐4, pRFHM1 Yeast strain: e.g., EGY48 (ura3 trp1 his3 3LexA ‐operator‐LEU2 ; see Table
Immunoglobulin Structure Home Page http://www.path.cam.ac.uk/~mrc7/mikeimages.htmlOverview of immunoglobulin structure and function, with many images of computer-rendered three-dimensional molecular models. V BASE — The Database of Human Antibody Genes
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