- ￥1375 - 5000
- Leading Biology
- AMM02472G
- 美国
- 2025年10月03日
- WB, IHC-P, FC
- Mouse
- H
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![ketohexokinase (KHK) Mouse Monoclonal Antibody [Clone ID: LBI2C3]](https://img1.dxycdn.com/2022/0707/344/1496323853485278553-14.jpg!wh200)
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- 详细信息
- 文献和实验
- 技术资料
- 靶点：
Vascular endothelial growth factor receptor 3, VEGFR-3, Fms-like tyrosine kinase 4, FLT-4, Tyrosine-protein kinase receptor FLT4, FLT4, VEGFR3
- 浓度：
Affinity Purification
- 应用范围：
WB, IHC-P, FC
- 宿主：
Mouse
- 适应物种：
H
- 保质期：
1-2年
- 供应商：
安诺伦（北京）生物科技有限公司
- 克隆性：
Monoclonal
- 保存条件：
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 形态：
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
- 免疫原：
Purified His-tagged VEGFR3 protein was used to produced this monoclonal antibody.
- 规格：
400 µl/200 µl/100 µl/50 µl
| 规格： | 400 µl | 产品价格： | ￥5000.0 |
|---|---|---|---|
| 规格： | 200 µl | 产品价格： | ￥3250.0 |
| 规格： | 100 µl | 产品价格： | ￥2250.0 |
| 规格： | 50 µl | 产品价格： | ￥1375.0 |
细胞定位：Cell membrane; Single-pass type I membrane protein Cytoplasm Nucleus. Note=Ligand-mediated autophosphorylation leads to rapid internalization [Isoform 2]: Cell membrane; Single-pass type I membrane protein
功能：Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.
总结：Tissue Location: Detected in endothelial cells (at protein level). Widely expressed. Detected in fetal spleen, lung and brain. Detected in adult liver, muscle, thymus, placenta, lung, testis, ovary, prostate, heart, and kidney.
稀释方法：WB--1:2000
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文献和实验PriCells: Primary cells culture with supplement of vascular endothelial growth factor (VEGF)
spanning region, and an intracellular portion containing a split tyrosine-kinase domain. VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF. The function of VEGFR
人血管内皮生长因子受体-1(sFlt-1)ELISA试剂盒 说明书
上海西唐生物科技有限公司 021-55229872, 65333639 www.westang.com 人血管内皮生长因子受体-1 ( sFlt-1 )ELISA 试剂盒 ( 用于血清、血浆、细胞培养上清液和其它生物体液内 ) 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗人 sFlt-1（ VEGFR1 ） 单抗包被于酶标板上，标准品和样品中的
determinant，抗原决定簇 ADA：adenosine deaminase，腺苷脱氨酶 ADCC：antibody-dependent cell-mediated cytotoxicity）抗体依赖细胞介导性细胞毒性 Adjuvant therapy：辅助治疗 AEL：acute erythrocytic leukemia，急性红白血病 AEoL：acute eosinophilic leukemia，急性嗜酸粒细胞白血病 aGVHD：acute graft versus host
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