- ￥1375 - 5000
- Leading Biology
- APR04710G
- 美国
- 2025年09月29日
- WB
- Rabbit
- H, Rat
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- 详细信息
- 文献和实验
- 技术资料
- 靶点：
Lysosomal-associated transmembrane protein 4B, Lysosome-associated transmembrane protein 4-beta, LAPTM4B
- 浓度：
Affinity Purification
- 应用范围：
WB
- 宿主：
Rabbit
- 适应物种：
H, Rat
- 保质期：
1-2年
- 供应商：
安诺伦（北京）生物科技有限公司
- 克隆性：
Polyclonal
- 保存条件：
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 免疫原：
This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 195-209 amino acids from human.
- 规格：
400 µl/200 µl/100 µl/50 µl
| 规格： | 400 µl | 产品价格： | ￥5000.0 |
|---|---|---|---|
| 规格： | 200 µl | 产品价格： | ￥3250.0 |
| 规格： | 100 µl | 产品价格： | ￥2250.0 |
| 规格： | 50 µl | 产品价格： | ￥1375.0 |
细胞定位：Endomembrane system; Multi-pass membrane protein. Late endosome membrane. Cell membrane. Cell projection. Lysosome membrane. Endosome membrane. Endosome, multivesicular body membrane. Endosome, multivesicular body lumen
功能：Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656).
稀释方法：WB--1:250 WB--1:1000
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文献和实验Interaction Trap/Two‐Hybrid System to Identify Interacting Proteins
of interest Plasmids (see Table 4.4.1 ): e.g., pEG202 (Fig. ), pSH18‐34 (Fig. ), pSH17‐4, pRFHM1 Yeast strain: e.g., EGY48 (ura3 trp1 his3 3LexA ‐operator‐LEU2 ; see Table
Immunoglobulin Structure Home Page http://www.path.cam.ac.uk/~mrc7/mikeimages.htmlOverview of immunoglobulin structure and function, with many images of computer-rendered three-dimensional molecular models. V BASE — The Database of Human Antibody Genes
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