Microphthalmia-associated transcription factor, Class E basic helix-loop-helix protein 32, bHLHe32, MITF, BHLHE32
浓度:
Affinity Purification
应用范围:
WB, IF, FC
宿主:
Rabbit
适应物种:
H
保质期:
1-2年
供应商:
安诺伦(北京)生物科技有限公司
克隆性:
Polyclonal
保存条件:
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
形态:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原:
This MITF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-28 amino acids from the N-terminal region of human MITF.
规格:
400 µl/200 µl/100 µl/50 µl
规格:
400 µl
产品价格:
¥5000.0
规格:
200 µl
产品价格:
¥3250.0
规格:
100 µl
产品价格:
¥2250.0
规格:
50 µl
产品价格:
¥1375.0
分子量:58795
细胞定位:Nucleus. Cytoplasm Note=Found exclusively in the nucleus upon phosphorylation
功能:Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
总结:Tissue Location:Expressed in melanocytes (at protein level). [Isoform C2]: Expressed in the kidney and retinal pigment epithelium. [Isoform H2]: Expressed in the kidney. [Isoform Mdel]: Expressed in melanocytes.