Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
库存:
100
宿主:
Goat
抗体名:
FAPP2
规格:
0.1 mg
分子量:
58261 Da
细胞定位:
Antigen Cellular Localization:Cytoplasm. Golgi apparatus, trans-Golgi network membrane. Membrane; Peripheral membrane protein Note=Mainly localized to the trans-Golgi network (TGN) but also found at the rims of Golgi cisternae. Associates with ARF1 at Golgi apparatus membranes
形式:
0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
参考文献:
FAPP2 gene downregulation increases tumor cell sensitivity to Fas-induced apoptosis. Tritz R, et al. Biochem Biophys Res Commun, 2009 May 29. PMID 19341712.Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. D'Angelo G, et al. Nature, 2007 Sep 6. PMID 17687330.FAPP2 is involved in the transport of apical cargo in polarized MDCK cells. Vieira OV, et al. J Cell Biol, 2005 Aug 15. PMID 16103222.FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Godi A, et al. Nat Cell Biol, 2004 May. PMID 15107860.Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.
产品概述:
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality Goat Anti-FAPP2 / PLEKHA8 antibody.
功能:
Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.
总结: