- $495
- Leading Biology
- United States
- APR11051G
- 2025年08月28日
- Rabbit
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
85-116 aa
- 保存条件：
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 库存：
100
- 宿主：
Rabbit
- 规格：
100 μl
23 KDa
细胞定位：
Antigen Cellular Localization: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
形式：
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
参考文献：
Keen T.J.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. Troy T.,et al.Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases. Clark H.F.,et al.Genome Res. 13:2265-2270(2003). Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases. Otsuki T.,et al.DNA Res. 12:117-126(2005).
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CLDN6 antibody.
功能：
Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity). May act as a coreceptor for HCV entry into hepatic cells.
总结：
Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity).
联系方式：
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文献和实验STM：广州医科大学刘铭/谢茂彬合作发现肝细胞癌的新潜在治疗靶点 Claudin 6
组于 Science Translational Medicine 杂志（STM）在线发表题为 Targeting tumor lineage plasticity in hepatocellular carcinoma using an anti-CLDN6 antibody-drug conjugate 的研究论文。这项研究揭示了细胞紧密连接（tight junction）蛋白 Claudin 6 通过调控肝癌细胞的谱系可塑性（lineage plasticity），促进肝癌进展与耐药的机制，并初步报道
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
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