Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
克隆性:
单克隆
库存:
100
宿主:
Mouse
应用范围:
IHC, IF, FC, IP, E
靶点:
Recombinant human CD11b protein
抗体名:
CD11B, CR3A
规格:
50 μg
分子量:
95kDa & 170kDa
细胞定位:
Antigen Cellular Localization:Membrane; Single-pass type I membrane protein
形式:
0.5 ml at 200ug/ml with BSA and azide
参考文献:
1. Springer T, et al. 1978. Eur. J. Immunol. 8:539. 2. Ault K and Springer T. 1981. J. Immunol. 126:359. 3. Springer TA, et al. 1982. Immunol. Rev. 68:171. 4. Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766. 5. Flotte TJ, et al. 1983. Am. J. Pathol. 111:112.
产品概述:
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality CD11b / MAC-1 (Microglial Marker) antibody - With BSA and Azide.
功能:
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
总结:
CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin åM combines with the Integrin ∫2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin åM/∫2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.
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