- $545
- Leading Biology
- United States
- APG02422G
- 2025年08月19日
- WB, IHC
- Rabbit
- Human, Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 克隆性：
单克隆
- 适应物种：
Human, Mouse
- 库存：
100
- 宿主：
Rabbit
- 应用范围：
WB, IHC
- 靶点：
A synthetic peptide corresponding to C-terminus of human Caspase-9 p35 subunit was used as immunogen. The antibody should recognize only pro-form (46kDa) .
- 抗体名：
MCH6
- 规格：
100 μl
46281 Da
细胞定位：
形式：
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
参考文献：
1. Kuida, K. et al. Reduced Apoptosis and Cytochrome c
2. Li, P. et al. Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade. Cell 91: 479
3. Duan, H. et al. ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J. Biol. Chem. 271: 16720
4. Srinivasula, S.M. et al. The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32. J. Biol. Chem. 271: 27099
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Caspase-9 antibody (Pro).
功能：
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP).
总结：
Caspase-9 (ICE-LAP6, Mch-6, Apaf-3) is a member of the cysteine aspartic acid protease, or caspase, family. Pro-Caspase-9 exists as a 46 kDa isomer that is cleaved by apoptotic stimulation, and functions as the major initiator caspase in programmed cell death, or apoptosis (1-4). Upon stimulation, cytochrome c is released from mitochondria, and associates with the Pro-Caspase-9/Apaf 1 complex. This complex in turn activates Pro-Caspase-9 by cleaving it into an active 35 kDa fragment and a small 10 kDa fragment (1,2). Activated Caspase-9 cleaves Caspase-3 as well as poly (ADP-ribose) polymerase (PARP) to initiate a caspase cascade and apoptosis (3,4).
联系方式：
生物商城：http://www.annoron.com
办公电话：010-56256916
官方售后：400-965-8633
企业 QQ：3212874516、3198592576
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