- $545
- Leading Biology
- United States
- APR07083G
- 2025年08月19日
- WB, IHC
- Rabbit
- Human, Mouse, Rat
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 克隆性：
单克隆
- 适应物种：
Human, Mouse, Rat
- 库存：
100
- 宿主：
Rabbit
- 应用范围：
WB, IHC
- 靶点：
A synthetic peptide corresponding to residues in the C-terminus of human Calmodulin was used as immunogen.
- 抗体名：
CALM, CAM, CAM1
- 规格：
100 μl
16838 Da
细胞定位：
Antigen Cellular Localization: Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules
形式：
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
参考文献：
1. Sasagawa T, Ericsson LH, Walsh KA, Schreiber WE, Fischer EH, Titani K. Biochemistry. 1982 May 11;21(10):2565-9. 2. Eldik L.V. and Watterson,D.M. (1998) Academic Press, San Diego, CA 3. Finn B.E., Evenas,J., Drakenberg,T., Waltho,J.P., Thulin,E. and Forsen,S. (1995) Nat. Struct. Biol., 2, 777 4. DeMaria C.D., Soong,T.W., Alseikhan,B.A., Alvania,R.S. and Yue,D.T. (2001) Nature, 411, 484 5. Deisseroth K., Heist,E.K. and Tsien,R.W. (1998) Nature, 392, 198
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Calmodulin antibody (CaM) (C-term).
功能：
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
总结：
Calmoduin (CaM) is a calcium modulator protein and a transducer of calcium signals (1-2). Upon calcium binding, calmodulin undergoes conformational changes and binds and modulates a diverse array of proteins. Calcium-bound CaM (Ca2+-CaM) can assume a variety of shapes depending on the target (3). Ca2+-CaM binds many kinases, phosphatases, signaling proteins, and structural proteins affecting a wide variety of processes including neurotransmitter release, muscle contraction, metabolism, apoptosis, inflammation, membrane protein organization, and cytoskeleton movement (2, 4-5).
联系方式：
生物商城：http://www.annoron.com
办公电话：010-56256916
官方售后：400-965-8633
企业 QQ：3212874516、3198592576
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文献和实验Studies of Calmodulin-Dependent Regulation
Methods are presented for purifying bovine testes calmodulin and the calmodulin-regulated plasma-membrane calcium ATPase from human erythrocytes by calcium dependent affinity chromatography. The assay of CaM Kinase II using a synthetic
Characterization of Calcium/Calmodulin- Stimulated Protein Kinase II
The enzyme Ca2+ /calmodulin-stimulated protein kinase II (CaM-PK II) belongs to a family of calmodulin-stimulated serine/threonine protein kinases that are widely distributed in nature, but are especially enriched in the brain (1 –3 ). CaM-PK
The Use of Dansyl-Calmodulin to Study Interactions with Channels and Other Proteins
of proteins, including ion channels, with the Ca2+ -dependent regulatory protein calmodulin. Here we describe the preparation and use of dansyl-calmodulin (D-CaM).
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