Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
克隆性:
单克隆
适应物种:
Human, Mouse, Rat
库存:
100
宿主:
Rabbit
应用范围:
WB
靶点:
A synthetic peptide corresponding to residues in human Alpha Fodrin was used as an immunogen.
抗体名:
NEAS, SPTA2
规格:
100 μl
分子量:
284539 Da
细胞定位:
Antigen Cellular Localization:Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells.
形式:
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
参考文献:
1. Leto TL, et al. Mol Cell Biol. 8(1):1-9, 1988
2. Simonovic M, et al. J Biol Chem. 281(45):34333-40, 2006
3. DH Giebelhaus, et al. The Journal of Cell Biology 105:843-853,1987
4. Martin SJ, et al. J Biol Chem. 270(12):6425-8, 1995
5. Ulbricht K U, et al. Autoimmunity Reviews 2(2):109-113,2003
6. Kahaly, G. J., et al. Clinical & Experimental Immunology 140:166-172(7), 2005
产品概述:
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality Alpha Fodrin antibody.
功能:
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
总结:
Alpha Fodrin is a member of the spectrin family of widely distributed filamentous proteins that form a supporting and organizing scaffold for cell membranes (1). Non-erythroid alpha spectrin, also called Alpha Fodrin, is a major cortical cytoskeletal protein that has been implicated in the establishment of specialized membrane- cytoskeletal domains in differentiating cells (2-3). Cleavage of Alpha Fodrin accompanies apoptosis, induced by activation via the CD3/T cell receptor complex, ligation of the Fas (CD95) molecule and other Fas-expressing cells, or treatment of cells with staurosporine, dexamethasone, or synthetic ceramide (4). The major products of the cleavage are amino-terminal (135 kDa) and carboxy-terminal (150 kDa and 120 kDa) fragments. Antibodies against Alpha Fodrin are observed in diseases characterized by chronic apoptosis, and are valuable in the evaluation fo Sicca- and Sj鰃ren's syndrome (5-6).
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