- ￥5040
- Adipogen
- 瑞士
- AG-20B-0010-C100
- 2025年07月16日
- ICC, IP, WB
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 供应商：
欣博盛生物
- 库存：
99
- 级别：
科研
- 克隆性：
单克隆
- 抗体英文名：
anti-ZBP1
- 抗体名：
anti-ZBP1
- 免疫原：
Recombinant mouse ZBP1 (aa 1-411).
- 应用范围：
ICC, IP, WB
- 浓度：
1mg/ml
- 规格：
100 ug
anti-ZBP1, mAb (Zippy-1)产品由Adipogen公司生产，产地是瑞士。该产品货号为AG-20B-0010-C100，包装规格是100 ug。如需购买该产品，询问折扣价/货期/技术问题，请联系Adipogen授权代理商——欣博盛生物
ZBP1是一种干扰素诱导蛋白，与细胞质DNA结合，在宿主防御肿瘤和病原体中发挥作用。ZBP1在淋巴结，白细胞，扁桃体，骨髓和脾脏等淋巴组织中高度表达。ZBP1是甲型流感病毒（IAV）的先天免疫传感器，它在IAV感染期间调节NLRP3（核苷酸和寡聚化结构域，富含亮氨酸重复序列的蛋白质家族，含有pyrin结构域3）炎性小体激活以及诱导不同类型的细胞死亡（细胞凋亡，坏死和焦亡）。
产品详情
别名：Z-DNA-binding Protein 1; Tumor Stroma and Activated Macrophage Protein DLM-1; DNA-dependent Activator of IFN-regulatory Factors; DAI
类型：Monoclonal Antibody
来源：Purified from concentrated hybridoma tissue culture supernatant.
应用：ICC, IP, WB
克隆号：Zippy-1
免疫原：Recombinant mouse ZBP1 (aa 1-411).
同种型：Mouse IgG2a
浓度：1mg/ml
纯度：>95% (SDS-PAGE)
产品检测实例
右图是使用该抗体对L929细胞中的小鼠ZBP1进行蛋白质印迹分析。提取未刺激的L929细胞的细胞裂解液（泳道1），用3μg/ml的poly(dA.dT) poly(dT.dA)刺激24小时（泳道2），在还原条件下通过SDS-PAGE，转膜到硝酸纤维素膜上，使用ZBP1 抗体孵育1小时后，显影成像结果。
该产品自上市以来有多篇文献引用，品质有保证，以下是最-新发表的文献引用：
1.ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation: R. De Reuver, et al.; Nature 607, 784 (2022)
2.ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection: R. Karki, et al.; Sci. Immunol. 7, eabo6294 (2022)
订购信息
| 品牌 | 产品名称 | 货号 | 规格 |
| Adipogen | anti-ZBP1, mAb (Zippy-1) | AG-20B-0010-C100 | 100 ug |
更多产品详情，请联系Adipogen一级代理-欣博盛生物
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- 作者
- 内容
- 询问日期
文献和实验- ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways: T. Kuriakose, et al.; Sci. Immunol. 1, aag2045 (2016)
- DAI senses Influenza A virus genomic RNA and activates RIPK3-dependent cell death: R.J. Thapa, et al.; Cell Host & Microbe 20, 674 (2016)
- RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation: J. Lin, et al.; Nature 540, 124 (2016)
- RIPK1 inhibits ZBP1-driven necroptosis during development: K. Newton, et al.; Nature 540, 129 (2016)
- IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection: T. Kuriakose, et al.; J. Immunol. 200, 1489 (2018)
- Necroptotic signaling is primed in Myco-bacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted: M.D. Stutz, et al.; Cell Death Differ. 25, 951 (2018)
- Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1: H. Guo, et al.; Cell Death Dis. 9, 816 (2018) [KO Validation]
- Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis: J. Sarhan, et al.; Cell Death Diff. 26, 332 (2019)
- ZBP1/DAI Drives RIPK3-Mediated Cell Death Induced by IFNs in the Ab-sence of RIPK1: J.P. Ingram, et al.; J. Immunol. 203, 1348 (2019)
- IRF3 and IRF7 contribute to diesel exhaust particles-induced pulmonary inflammation by mediating mTORC1 activation and restraining autophagy in mice: C. Wang, et al.; Eur. J. Immunol. 50, 1142 (2020)
- Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis: T. Zhang, et al.; Cell 180, 1115 (2020)
- Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation: H. Jiao, et al.; Nature 580, 391 (2020)
- Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense: M. Zheng, et al.; Cell 181, 674 (2020)
- Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis): S. Christgen, et al.; Front. Cell.Infect. Microbiol. 10, 237 (2020)
- ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis): B. Banoth, et al.; J. Biol. Chem. 295, P18276 (2020)
- ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1: H.I. Muendlein, et al.; Nat. Commun. 12, 86 (2021)
- Vaccinia virus E3 prevents sensing of Z-RNA to block ZBP1-dependent necroptosis: H. Koehler, et al.; Cell Host Microbe 29, 1 (2021)
- ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer: J.Y. Baik, et al.; Nature Commun. 12, 2666 (2021)
- Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA-cGAS-STING Signaling Axis: S. Torres-Odio, et al.; J. Immunol. 206, 1890 (2021)
- ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis: R. Karki, et al.; Cell Rep. 37, 109858 (2021)
- Z-DNA binding protein 1 mediates necroptotic and apoptotic cell death pathways in murine astrocytes following herpes simplex virus-1 infection: A.M. Jeffries, et al.; J. Neuroinflamm. 19, 109 (2022)
- ADAR1 mutation causes ZBP1-dependent immunopathology: N.W. Hubbard, et al.; Nature 607, 769 (2022)
- ADAR1 averts fatal type I interferon induction by ZBP1: H. Jiao, et al.; Nature 607, 776 (2022)
- ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation: R. De Reuver, et al.; Nature 607, 784 (2022)
- ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection: R. Karki, et al.; Sci. Immunol. 7, eabo6294 (2022)
- Necroptosis of macrophage is a key pathological feature in biliary atresia via GDCA/S1PR2/ZBP1/p-MLKL axis: S. Yang, et al. Nature Cell Death Dis. 14, 175 (2023)
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