产品名称:PRPK抗体 产品分类 抗体 / 一抗 英文名称 PRPK 中文名称 TP53调节激酶抗体 英文别名 C20orf64; Nori 2; Nori 2p; Nori-2; p53 related protein kinase; p53-related protein kinase; PRPK_HUMAN; TP53 regulating kinase; TP53-regulating kinase; TP53RK. 交叉反应 Human, Mouse, Rat, Dog 标记 Unconjugated 抗体来源 Rabbit 抗体类型 Polyclonal 免疫原 KLH conjugated synthetic peptide derived from human PRPK 蛋白细胞定位 细胞核 纯化方法 affinity purified by Protein A 亚型 IgG 性状 Liquid 浓度 1mg/ml 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 背景资料 PRPK is a 253 amino acid protein kinase that phosphorylates Ser15 of p53. PRPK phosphorylation of p53 causes increased stabilization and activity of p53. CGI-121 may act as an inhibitor of the PRPK-p53 interaction, thus preventing the phosphorylation of p53. Unphosphorylated p53 is degraded by the ubiquitin-proteasome pathway, which may ultimately lead to cell proliferation. PRPK contains a protein kinase domain with a conserved catalytic core. PRPK is localized to the nucleus of the cell and is highly expressed in testis, with lower expression in heart, kidney and spleen.