AS2863619

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

AS2863619

CAS No. : 2241300-51-4

MCE 国际站：AS2863619

产品活性：AS2863619 可以将抗原特异性效应子/记忆 T 细胞转换为 Foxp3⁺ 调节性 T (T_reg) 细胞，以研究各种免疫疾病。AS2863619 是一种有效的口服的细胞周期蛋白依赖性激酶 8 (CDK8) 和 CDK19 抑制剂，IC₅₀ 分别为 0.61 nM 和 4.28 nM。AS2863619 抑制 CDK8/19 可增强 STAT5 的激活，从而激活 Foxp3 基因。

研究领域：Cell Cycle/DNA Damage  |  Stem Cell/Wnt  |  JAK/STAT Signaling

作用靶点：CDK  |  STAT

In Vitro: AS2863619 (1 μM; 22 hours; mouse CD4⁺ T cells) treatment suppresses serine phosphorylation of the PSP motif of STAT5b to ~40% while enhancing tyrosine phosphorylation in the C-terminal domain to ~160% of control-treated samples.

In Vivo: AS2863619 (30 mg/kg; oral administration; daily; for 2 weeks; mice) treatment after sensitization with 2,4-dinitrofluorobenzene (DNFB) dampens the degree of the secondary response, with milder infiltration of inflammatory cells into the skin and decreases ratios of interferon-γ⁺ (IFN-γ⁺) cells in a skin contact hypersensitivity model, when compared with vehicle-treated control mice. T_reg depletion before the elicitation of the secondary response abolishes AS2863619-induced suppression. KLRG1⁺ Foxp3⁺ T cells are specifically increased in DNFB sensitized AS2863619-treated mice.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Immunology/Inflammation Compound Library  |  JAK/STAT Compound Library  |  Kinase Inhibitor Library  |  Stem Cell Signaling Compound Library  |  Anti-Aging Compound Library  |  Orally Active Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Transcription Factor-Targeted Library  |  Anti-Pulmonary Fibrosis Compound Library  |  Cancer Stem Cells Compound Library  |  Heterocyclic Compound Library  |  Membrane Protein-targeted Compound Library  |  Highly Selective Inhibitors Library  |  Highly Selective Activators Library  |  Serine/Threonine Kinase Inhibitor Library  |  Palbociclib  |  Stattic  |  Abemaciclib  |  Fludarabine  |  Ro-3306  |  Ribociclib  |  AG490  |  Dinaciclib  |  Cilengitide  |  Niclosamide  |  GSK3326595  |  Homoharringtonine  |  Artesunate  |  THZ1  |  Flavopiridol  |  C188-9  |  AS1517499  |  Colivelin TFA  |  SR-4835  |  (R)-Roscovitine  |  THZ531  |  AZD4573  |  TPCA-1  |  SY-5609  |  Napabucasin  |  NSC 74859  |  WP1066  |  Kenpaullone

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds