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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
6533-00-2
- 规格：
10 mM * 1 mL/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥500.0 |
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Norgestrel
CAS No. : 6533-00-2
MCE 国际站：Norgestrel
产品活性：Norgestrel 是孕酮的合成类似物，是口服避孕药中常见的化合物，也是一种强大的神经保护性抗氧化剂，可防止光诱导的感光细胞中的 ROS 的生成以及细胞死亡。Norgestrel 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。
研究领域：Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease
In Vitro: Norgestrel (20 µM; 24 hours; 661W cells) treatment significantly increases cellular viability after serum deprivation and so it is demonstrated that Norgestrel is neuroprotective to stressed 661W cells.
Norgestrel (20 µM; 24 hours; 661W cells) treatment decreases apoptotic induced cleavage of PARP and caspase-3.
Norgestrel (20 µM; 6 hours; 661W cells) treatment bFGF is results in a significant upregulation of bFGF mRNA in photoreceptor cells.
In Vivo: Norgestrel (100 mg/kg; intraperitoneal injection; for 6, 24 or 48 hours; Balb/c mice) treatment can prevent light-induced ROS in photoreceptor cells, and subsequent cell death. Norgestrel acts via post-translational modulation of the major antioxidant transcription factor Nrf2; bringing about its phosphorylation, subsequent nuclear translocation, and increases levels of its effector protein superoxide dismutase 2 (SOD2).
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文献和实验，甲基炔诺酮，norgestrel）等。 【体内过程】黄体酮口服后在胃肠及肝迅速破坏，效果差，故采用注射给药。血浆中的黄体酮大部分与蛋白结合，游离的仅占3%。其代谢产物主要与葡萄糖醛酸结合，从肾排出，人工合成的炔诺酮、甲地孕酮等作用较强，在肝破坏较慢，可以口服，是避孕药的主要成分。油溶液肌内注射可发挥长效作用。 【生理及药理作用】 1.生殖系统 （1）当月经后期，在雌激素作用的基础上，使子宫内膜继续增厚、充血、腺体增生并分支，由增殖期转为分泌期，有利于孕卵
炔诺醇（etynodiol diacetate）、炔诺孕酮（18甲基炔诺酮，甲基炔诺酮，norgestrel）等。 【体内过程】黄体酮口服后在胃肠及肝迅速破坏，效果差，故采用注射给药。血浆中的黄体酮大部分与蛋白结合，游离的仅占3%。其代谢产物主要与葡萄糖醛酸结合，从肾排出，人工合成的炔诺酮、甲地孕酮等作用较强，在肝破坏较慢，可以口服，是避孕药的主要成分。油溶液肌内注射可发挥长效作用。 【生理及药理作用】 1.生殖系统 （1）当月
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