SEW​2871,256414-75-2

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SEW​2871

CAS No. : 256414-75-2

MCE 国际站：SEW​2871

产品活性：SEW2871 是一种口服有效的、高选择性的 S1P1 (鞘氨醇 -1- 磷酸 1 型受体)激动剂，其 EC₅₀ 为 13.8 nM。SEW2871 可激活 ERK，Akt 和 Rac 信号通路，并诱导 S1P1 内化和循环。SEW2871 可减少血液中的淋巴细胞数量。SEW2871 可用于糖尿病，阿尔茨海默氏病，肝纤维化和炎症的研究。

研究领域：GPCR/G Protein  |  Stem Cell/Wnt  |  MAPK/ERK Pathway  |  PI3K/Akt/mTOR

作用靶点：LPL Receptor  |  ERK  |  Akt

In Vitro: SEW2871 exerts a powerful migratory effect by increasing smooth muscle α-actin, procollagen αI and αIII, and total hydroxyproline contents in LX-2 cells (a human hepatic stellate cell line).

In Vivo: SEW2871 (20 mg/kg, Gavage, once daily for 2 weeks) ameliorates established experimental colitis in IL-10^–/– mice.
?SEW2871 (0.5 mg/kg, IP, daily for 2 weeks) inhibited β amyloid (Aβ_1-42)-induced spatial memory impairment and hippocampal neuronal loss in a rat model of Alzheimer’s disease.
?SEW2871 (0-0.3 mg/kg, IV) attenuates LPS-induced acute inflammatory lung injury, produces dose-dependent alveolar and vascular barrier protection in C57Bl/6 mice.
?SEW2871 is effective in protecting kidneys against ischaemia-reperfusion injury by reducing CD4⁺ T cell infiltration in mice.

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