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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
江西江蓝纯生物试剂有限公司
- 库存:
127
- 克隆性:
单克隆
- 保质期:
1年
- 抗体英文名:
C1QL1
- 抗体名:
补体组分1q子成分样蛋白1抗体
- 适应物种:
人/动物/植物
- 应用范围:
WB,ELISA等
- 浓度:
1mg/ml
- 保存条件:
-20 °
- 规格:
100ul/200ul
| 规格: | 100ul | 产品价格: | ¥1580.0 |
|---|---|---|---|
| 规格: | 200ul | 产品价格: | ¥2480.0 |
英文名称 : C1QL1
中文名称 : 补体组分1q子成分样蛋白1抗体
别 名 : C1q related factor; C1q-related factor; C1ql1; C1QRF; C1QRF_HUMAN; C1QTNF14; Complement component 1 Q subcomponent like 1; Complement component 1 Q subcomponent-like 1; CRF; Gliacolin.
研究领域 : 神经生物学 细胞粘附分子
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Dog, Pig, Cow,
产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 25kDa
细胞定位 : 分泌型蛋白
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human C1QL1:21-120/258
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : C1q is part of the C1 enzyme complex, which activates the serum complement system. The residues of the globular domain in C1q share homology with several other secreted and membrane-bound collagen or collagen-like proteins, including pre-cerebellin and collagen types VIII and X, as well as the human and mouse genes encoding Apm1/BPB80 and AdipoQ/ACRP30, respectively. These various C1q-related proteins are found in adipose serum, corneal endothelium, chondrocytes and cerebral Purkinje cells. C1qL1 (complement component 1, q subcomponent-like 1), also known as CRF or C1QRF, is a polypeptide with a hydrophobic signal sequence, a collagenous region and a globular domain at the carboxy terminus, which shares homology to the C1q globular domain. C1qL1 transcripts are most abundant in areas of the nervous system that are associated with motor function, including cerebral Purkinje cells, the pons, the accessory olivary nucleus, and the red nucleus. The similarity of mouse C1qL1 to human C1qL1 suggests a conserved and important role for the protein. In humans, the gene encoding C1qL1 maps to chromosome 17q21.
Function:
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).
Subunit:
Interacts with BAI3 (By similarity).
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in brainstem.
Similarity:
Contains 1 C1q domain.
Contains 1 collagen-like domain.
SWISS:
O75973
Gene ID:
10882
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片
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文献和实验网络 第五章 补体的分子生物学 补体系统由30多种蛋白分子所组成,是迄今所知机体中最复杂的一个限制性蛋白水解系统(limited proteolysis system),根据各成分功能不同,将它们分为三组。第一组为补体系统的固有成分共14个蛋白分子。即C1(含三个亚组分:C1q、Clr和Cls)、C4、C2、C3、C5、C6
社交能力还和肠道有关?新研究揭示肠道菌群如何控制大脑和社交行为
酸代谢和线粒体功能相关基因的表达。在分枝状的小胶质细胞中,菌群抑制了溶酶体基因的表达,同时促进蛋白酶体基因的表达。在这些细胞中,微生物群还促进了其他部分基因的表达,包括对革兰氏阳性菌的防御反应、I-kB 激酶/NF-kB 信号的调节,这表明小胶质细胞对微生物信号的反应受到影响。 GO 分析表明,微生物群改变了小胶质细胞中的溶酶体和蛋白酶体的功能。此外,微生物群还促进了重塑小胶质细胞的其他通路,特别是补体信号通路,并明显促进了分枝状小胶质细胞突触重塑因子 c1q 的表达。 图片来源:PLOS
中正常存在的、与免疫有关并具有酶样活性的一组球蛋白。在本世纪60年代,随着人们分离、提取补体成分的成功,证明补体是包含多种成分的血浆蛋白,故又称补体系统。其中包括了参与补体激活的成分,也包括了调控补体系统的各种灭活因子的抑制因子。补体系统在人体的免疫应答及免疫适应中起着非常重要的作用。它作为机体非特异性免疫的因素之一,在非特异性免疫中起重要作用。同时,通过免疫调理、免疫粘附、中和病毒、溶菌杀菌等,在特异性免疫中也担当着重要角色。目前,国内外对于运动与补体的研究较少。这可能与人们公认补体在血液中含量相对稳定、与抗原
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