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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
江西江蓝纯生物试剂有限公司
- 库存:
120
- 克隆性:
单克隆
- 保质期:
1年
- 抗体英文名:
C1QTNF10
- 抗体名:
补体C1q和肿瘤坏死因子相关蛋白10抗体
- 适应物种:
人/动物/植物
- 应用范围:
WB,ELISA等
- 浓度:
1mg/ml
- 保存条件:
-20 °
- 规格:
100ul/200ul
| 规格: | 100ul | 产品价格: | ¥1580.0 |
|---|---|---|---|
| 规格: | 200ul | 产品价格: | ¥2480.0 |
英文名称 : C1QTNF10
中文名称 : 补体C1q和肿瘤坏死因子相关蛋白10抗体
别 名 : C1q and tumor necrosis factor related protein 10; C1q domain containing protein; C1QL2; C1QL2_HUMAN; C1QTNF10; Complement C1q-like protein 2; Complement component 1, q subcomponent-like 2; CTRP10; gliacolin like.
研究领域 : 细胞生物 免疫学
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 IEM=1:20-200 IGS=1:20-200 GICA=1:20-200 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 27kDa
细胞定位 : 分泌型蛋白
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human C1QL2/C1QTNF10:101-200/187
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
PubMed : PubMed
产品介绍 : C1qL2, also known as CTRP10 or C1QTNF10, is a 287 amino acid secreted protein that contains one C1q domain and one collagen-like domain. C1qL2 belongs to a large family of multimeric proteins with a signature globular domain homologous to C1QA. These proteins also share structural homology with TNF family members. The gene that encodes C1qL2 consists of approximately 2,653 bases and maps to human chromosome 2q14.2. Consisting of 237 million bases, chromosome 2 encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr鰉 syndrome, is due to mutations in the ALMS1 gene.
Function:
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).
Subunit:
Forms homotrimers which can further assemble to form higher-order oligomeric complexes (By similarity). Interacts with BAI3 (By similarity). May interact with FAM132B (By similarity).
Subcellular Location:
Secreted.
Similarity:
Contains 1 C1q domain.
Contains 1 collagen-like domain.
SWISS:
Q7Z5L3
Gene ID:
165257
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片
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文献和实验病毒、巨细胞病毒、牛白蛋白和马蛋白等。 (二)补体相关测定法 IgG和IgM类抗体与抗原结合后,重链CH2区的补体结合点暴露,可以固定C1q并激活补体的系列反应,这是利用补体有关技术检测免疫复合物的基础。 1.C1q结合试验将待检血清先行加热56℃30min,以灭活其中的补体和破坏已与CIC结合的C1q,空出补体结合点。CIC与C1q的结合可用多种方法进行检测,常用的有以下3种医学教育网`搜集整理。 (1)液相法:先将同位素标记的C1q与灭活过的血清标本混合作用,再加
适于研究溶解度1、PEG沉淀20μg粗定量,易推广2、冷沉淀——定性,临床应用补体法固定补体,结合C1q抗补体试验0.1μg常用,特异性差1、C1q凝胶沉淀试验100μg定性,不易普及2、C1q偏离试验4μg不易普及3、液相法10μg不易普及4、固相法1μg不易普及胶固素胶固素结合试验3μg敏感,稳定抗Ig法结合RF1、RF凝胶沉淀试验100G定性,不敏感2、mRF固相抑制试验1~20μg不易普及3、PRF凝集抑制试验1~10μg不易普及结合Ig抗抗体法2~3μg不易普及细胞法Fc受体1、血小
它们。 7. 母乳中的分泌型IgA提高了婴儿出生后4~6个月内的局部免疫屏障,常称为局部抗体。 8. 人类重链基因位于14号染色体上,K基因位于第二号染色体上。 9. 参与补体激活经典途径的固有成份按先后为C1,C2……C9,C1由C1q,C1r,C1s,三种组成。灭活的补体在片在符号前加i,有酶活性的上加一横。 10. 补体大多是糖蛋白多属β球蛋白,C1q,C8是γ蛋白。C1s,C9是α球蛋白。C3含量最多,C2含量最少。替代途经的激活物主要是细胞壁成分。 11. 补体清除免疫复合
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