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- jlcR17063
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
江西江蓝纯生物试剂有限公司
- 库存：
182
- 克隆性：
单克隆
- 保质期：
1年
- 抗体英文名：
Kindlin
- 抗体名：
整合素相互作用蛋白Kindlin抗体
- 适应物种：
人/动物/植物
- 应用范围：
WB,ELISA等
- 浓度：
1mg/ml
- 保存条件：
-20 °
- 规格：
100ul/200ul
| 规格： | 100ul | 产品价格： | ¥1580.0 |
|---|---|---|---|
| 规格： | 200ul | 产品价格： | ¥2480.0 |
产品货号 : jlcR17063
英文名称 : Kindlin
中文名称 : 整合素相互作用蛋白Kindlin抗体
别 名 : C20orf42; Chromosome 20 open reading frame 42; DTGCU 2; DTGCU2; FERM1_HUMAN; Fermitin family homolog 1; Fermt1; FLJ20116; FLJ23423; KIND 1; KIND1; Kinderlin; Kindlerin; Kindlin 1; Kindlin syndrome protein; Kindlin-1; Kindlin1; Unc 112 related protein 1; Unc-112-related protein 1; Unc112 related protein; UNC112A; URP 1; URP1.
研究领域 : 肿瘤 细胞生物 肿瘤细胞生物标志物
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep,
产品应用 : ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 77kDa
细胞定位 : 细胞浆
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human Kindlin:601-677/677
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome. [provided by RefSeq, Dec 2009]
Function:
Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression.
Subcellular Location:
Cytoplasm > cytoskeleton. Cell junction > focal adhesion. Cell projection > ruffle membrane. Constituent of focal adhesions. Localized at the basal aspect of skin keratinocytes, close to the cell membrane. Colocalizes with filamentous actin. Upon TGFB1 treatment, it localizes to membrane ruffles.
Tissue Specificity:
Expressed in brain, skeletal muscle, kidney, colon, adrenal gland, prostate, and placenta. Weakly or not expressed in heart, thymus, spleen, liver, small intestine, bone marrow, lung and peripheral blood leukocytes. Overexpressed in some colon and lung tumors. In skin, it is localized within the epidermis and particularly in basal keratocytes. Not detected in epidermal melanocytes and dermal fibroblasts.
DISEASE:
Defects in FERMT1 are the cause of Kindler syndrome (KINDS) [MIM:173650]. An autosomal recessive skin disorder characterized by skin blistering, photosensitivity, progressive poikiloderma, and extensive skin atrophy. Additional clinical features include gingival erosions, ocular, esophageal, gastrointestinal and urogenital involvement, and an increased risk of mucocutaneous malignancy. Note=Although most FERMT1 mutations are predicted to lead to premature termination of translation, and to loss of FERMT1 function, significant clinical variability is observed among patients. There is an association of FERMT1 missense and in-frame deletion mutations with milder disease phenotypes, and later onset of complications (PubMed:21936020).
Similarity:
Belongs to the kindlin family.
Contains 1 FERM domain.
Contains 1 PH domain.
SWISS:
Q9BQL6
Gene ID:
55612
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Kindlin家族是新近发现的粘着斑蛋白（focal adhesion protein），有3个成员（Kindlin-1、Kindlin-2、Kindlin-3）。Kindlin家族参与整合素活化、细胞迁移、增殖和分化的调控，在临床上与皮肤疾病发生、肿瘤的侵袭、心血管生成、免疫系统功能有密切关系。Kindlins异常可以导致多种遗传性疾病，如Kindlin-1功能异常导致Kindler综合征（Kindler syndrome，KS）和Kindlin-3功能异常导致白细胞黏附缺陷（1eukocyte adhesion deficiency，LAD—HI）。目前已在人类实体肿瘤（乳腺癌、前列腺癌、平滑肌肉瘤）中发现Kindlin-2与肿瘤的侵袭性及耐药性有关。
产品图片
英文名称 : Kindlin
中文名称 : 整合素相互作用蛋白Kindlin抗体
别 名 : C20orf42; Chromosome 20 open reading frame 42; DTGCU 2; DTGCU2; FERM1_HUMAN; Fermitin family homolog 1; Fermt1; FLJ20116; FLJ23423; KIND 1; KIND1; Kinderlin; Kindlerin; Kindlin 1; Kindlin syndrome protein; Kindlin-1; Kindlin1; Unc 112 related protein 1; Unc-112-related protein 1; Unc112 related protein; UNC112A; URP 1; URP1.
研究领域 : 肿瘤 细胞生物 肿瘤细胞生物标志物
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep,
产品应用 : ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 77kDa
细胞定位 : 细胞浆
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human Kindlin:601-677/677
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome. [provided by RefSeq, Dec 2009]
Function:
Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression.
Subcellular Location:
Cytoplasm > cytoskeleton. Cell junction > focal adhesion. Cell projection > ruffle membrane. Constituent of focal adhesions. Localized at the basal aspect of skin keratinocytes, close to the cell membrane. Colocalizes with filamentous actin. Upon TGFB1 treatment, it localizes to membrane ruffles.
Tissue Specificity:
Expressed in brain, skeletal muscle, kidney, colon, adrenal gland, prostate, and placenta. Weakly or not expressed in heart, thymus, spleen, liver, small intestine, bone marrow, lung and peripheral blood leukocytes. Overexpressed in some colon and lung tumors. In skin, it is localized within the epidermis and particularly in basal keratocytes. Not detected in epidermal melanocytes and dermal fibroblasts.
DISEASE:
Defects in FERMT1 are the cause of Kindler syndrome (KINDS) [MIM:173650]. An autosomal recessive skin disorder characterized by skin blistering, photosensitivity, progressive poikiloderma, and extensive skin atrophy. Additional clinical features include gingival erosions, ocular, esophageal, gastrointestinal and urogenital involvement, and an increased risk of mucocutaneous malignancy. Note=Although most FERMT1 mutations are predicted to lead to premature termination of translation, and to loss of FERMT1 function, significant clinical variability is observed among patients. There is an association of FERMT1 missense and in-frame deletion mutations with milder disease phenotypes, and later onset of complications (PubMed:21936020).
Similarity:
Belongs to the kindlin family.
Contains 1 FERM domain.
Contains 1 PH domain.
SWISS:
Q9BQL6
Gene ID:
55612
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Kindlin家族是新近发现的粘着斑蛋白（focal adhesion protein），有3个成员（Kindlin-1、Kindlin-2、Kindlin-3）。Kindlin家族参与整合素活化、细胞迁移、增殖和分化的调控，在临床上与皮肤疾病发生、肿瘤的侵袭、心血管生成、免疫系统功能有密切关系。Kindlins异常可以导致多种遗传性疾病，如Kindlin-1功能异常导致Kindler综合征（Kindler syndrome，KS）和Kindlin-3功能异常导致白细胞黏附缺陷（1eukocyte adhesion deficiency，LAD—HI）。目前已在人类实体肿瘤（乳腺癌、前列腺癌、平滑肌肉瘤）中发现Kindlin-2与肿瘤的侵袭性及耐药性有关。
产品图片
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文献和实验相关实验
CDD | 北大张宏权 / 于宇 / 祁丽花课题组揭示整合素相互作用蛋白 Kindlin-2 引发肥厚性心肌病的分子机制
。2019 年 11 月 26 日，来自北京大学基础医学院的张宏权教授团队在 Cell Death and Disease 杂志上发表题为《Kindlin- 2 suppresses transcription factor GATA4 through interaction with SUV39 H1 to attenuate hypertrophy》的研究论文。该研究发现整合素相互作用蛋白 Kindlin- 2 通过调控组蛋白 H3K9 甲基化抑制 GATA4 的表达，保护心脏免于异丙
1. 前言 蛋白质芯片包含几百甚至几千个已知的蛋白样品，这些蛋白样品有序、高密度排列在镀膜玻璃板上。利用这些蛋白质芯片可以对蛋白质的表达 [5~7] 和修饰 [ 8~ 11] 进行平行、快速和简易的分析，同时也可以用来检测这些蛋白质与抗体、其他蛋白 [ 16，17] 、DNA [ 18，19 ] 或其他小分子 [ 20，21 ] 之间的相互作用。已有一些研究工作使用蛋白质抗原芯片分析特异性抗体 [ 12，15 ] 或从患有不同疾病的病人中筛选血清 [ 15，22，23 ] 。蛋白质组芯片
了一线技术支持常被问到的问题，希望这篇纯干货能帮助大家顺利升级打怪，早日驾驭 IP、co-IP。 IP、co-IP、pull-down 简介 IP（Immunoprecipitation），免疫沉淀：是利用固定在磁珠或琼脂糖树脂等基质上的特异性抗体对抗原进行小型亲和纯化的一种方法 Co-IP（co-Immunoprecipitation），免疫共沉淀： co-IP 是一种常用的鉴定蛋白-蛋白相互作用的方法，其基本实验流程和IP类似，通过使用诱饵蛋白（IP 中的抗原，bait protein）特异
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整合素相互作用蛋白Kindlin抗体
¥1580 - 2480
