产品货号 : jlcR12032 英文名称 : GRASP 中文名称 : 一般受体磷酸肌醇相关支架蛋白1抗体 别 名 : General Receptor for phosphoinositides 1; GRASP1; General receptor for phosphoinositides 1-associated scaffold protein; GRASP; GRASP_HUMAN; GRP1 (general receptor for phosphoinositides 1) associated scaffold protein; GRP1 associated scaffold protein; GRP1-associated scaffold protein; Tamalin. 研究领域 : 神经生物学 细胞膜受体 细胞骨架 抗体来源 : Rabbit 克隆类型 : Polyclonal 交叉反应 : Human, Mouse, Rat, Dog, Pig, Cow, Horse, 产品应用 : ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 : 45kDa 细胞定位 : 细胞浆 细胞膜 性 状 : Lyophilized or Liquid 浓 度 : 1mg/ml 免 疫 原 : KLH conjugated synthetic peptide derived from human GRASP/General Receptor for phosphoinositides 1:156-260/395 亚 型 : IgG 纯化方法 : affinity purified by Protein A 储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed : PubMed 产品介绍 : This gene encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. The encoded protein contains conserved domains, including a leucine zipper sequence, PDZ domain and a C-terminal PDZ-binding motif. Alternately spliced transcript variants have been observed for this gene.[provided by RefSeq, Dec 2012]
Function: Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.
Subunit: Heteromer. Composed of GRASP, PSCD2 and at least one GRM1. Also interacts with PSCD3, GRM2, GRM3 and GRM5
Subcellular Location: Cytoplasm, perinuclear region (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity). Note=Localized at postsynaptic membranes.
Similarity: Contains 1 PDZ (DHR) domain.
SWISS: Q7Z6J2
Gene ID: 160622
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.