相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 供应商:
江西江蓝纯生物试剂有限公司
- 库存:
99
- 克隆性:
单克隆
- 保质期:
1年
- 抗体英文名:
Glycophorin A
- 抗体名:
血型糖蛋白A/涎糖蛋白抗体
- 适应物种:
人/动物/植物
- 应用范围:
WB,ELISA等
- 浓度:
1mg/ml
- 保存条件:
-20 °
- 规格:
100ul/200ul
| 规格: | 100ul | 产品价格: | ¥1580.0 |
|---|---|---|---|
| 规格: | 200ul | 产品价格: | ¥2480.0 |
英文名称 : Glycophorin A
中文名称 : 血型糖蛋白A/涎糖蛋白抗体
别 名 : Glycophorin A; AI853584; CD235a; GPA; Blood group-MN locus; CD235a antigen; Glycophorin A (MNS blood group); Glycophorin A includes MN blood group; Glycophorin A precursor; Glycophorin A, included; GlycophorinA; GPA; GPErik; GpMiIII; GPSAT; GYPA; GYPA, included; HGpMiIII; HgpMiV; HgpMiX; HgpMiXI; HGpSta(C); MN; MN sialoglycoprotein; MNS; PAS 2; PAS-2; PAS2;Sialoglycoprotein alpha; GLPA_HUMAN.
研究领域 : 细胞生物 免疫学
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human,
产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-F=1:400-800 Flow-Cyt=3ug/test ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 14kDa
细胞定位 : 细胞膜
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human CD235a:21-120/150 <Extracellular>
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008].
Function:
Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).
Subunit:
Homodimer. Interacts with Streptococcus gordonii has protein.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Note=Appears to be colocalized with SLC4A1.
Similarity:
Belongs to the glycophorin A family.
SWISS:
P02724
Gene ID:
2993
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片
风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验血型糖蛋白又称涎糖蛋白(sialo glycoprotein),因它富含唾液酸。血型糖蛋白是第一个被测定氨基酸序列的蛋白质,有几种类型,包括A、B、C、D。血型糖蛋白B、C、D在红细胞膜中浓度较低。血型糖蛋白A是一种单次跨膜糖蛋白, 由131个氨基酸组成, 其亲水的氨基端露在膜的外侧, 结合16个低聚糖侧链。血型糖蛋白的基本功能可能是在它的唾液酸中含有大量负电荷,防止了红细胞在循环过程中经过狭小血管时相互聚集沉积在血管中。
。 MN血型红细胞膜上另一类血型抗原叫MN抗原,即红细胞膜上的血型糖蛋白A。它在SOS凝胶电泳谱上显示两条区带,即PAS-1和PAS-2,血型糖蛋白A是两者的二聚物。已知血型糖蛋白A由131个氨基酸组成,其一级结构已测定(图2)。血型糖蛋白A的肽链呈三节式结构,中间第73~92号氨基酸为疏水性肽链,可横穿膜脂层;N端肽链位于膜外侧,与血型活性有关,在这段肽链上分布有15条O-糖苷键型糖链和1条N-糖苷键型糖链,糖链中唾液酸占红细胞膜上全部唾液酸的一半以上;C端肽链位于膜内侧,含较多酸性氨
刷新认知!Nature Genetics 报道血型是如何决定肠道微生物组成的
与 ABO 血型等位基因和 FUT2 分泌状态的流行特征和丰度显著相关。Y 轴代表所调查的 9 个模型;交互作用由冒号表示;X 轴表示各模型的 z 分数。数据符号是根据队列来着色的,黑色菱形代表 5 个队列的元分析结果。符号大小代表绝对效果大小。P 值 研究意义 ABO 血型系统的基因决定了一个人属于哪种血型,分泌型的血型抗原不仅在红细胞表面形成,还能以分泌物的形式在粘膜表面合成,以糖基的形式释放到肠道中。拟杆菌类的一些细菌可能将这些糖基作为能量来源,从而大量繁殖。尤其对于 A、B 或 AB 血型
技术资料暂无技术资料 索取技术资料










