重组人BAFF优惠促销

特别提示：包括重组人BAFF在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人BAFF
英文名称：Recombinant Human B Cell Activating Factor
产品货号：GS4831
产品规格：5μg

分子量：Approximately 17.2kDa,a single non-glycosylated polypeptide chain containing 153 amino acids.
储存条件：冷冻（-20℃）

概述

B-cell activating factor(BAFF),also known as Blys,TALL-1,TNAK,and zTNF4,is a TNF ligand superfamily member and has been designated TNFSF13B.Produced by macrophages,dendritic cells,and T lymphocytes,BAFF promotes the survival of B cells and is essential for B cell maturation.BAFF binds to three TNF receptor superfamily members:B-cell maturation antigen(BCMA/TNFRSF17),transmembrane activator and calcium-modulator and cyclophilin ligand interactor(TACI/TNFRSF13B)and BAFF receptor(BAFF R/BR3/TNFRSF 13C).These receptors are type III transmembrane proteins that lack a signal peptide.Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand,APRIL(a proliferation-inducing ligand),BAFF R selectively binds BAFF.The BAFF R extracellular domain lacks the TNF receptor canonical cysteine-rich domain(CRD)and contains only a partial CRD with four cysteine residues.Human and mouse BAFF R share 56%a.a.sequence identity.BAFF R is highly expressed in spleen,lymph node and resting B cells.It is also expressed at lower levels in activated B cell,in resting CD4+ T cells,in thymus and peripheral blood leukocytes.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞95%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by a mouse splenocyte survival assay is 0.5-2μg/ml.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.0.
内毒素	Less than 1 EU/μg of rHuBAFF as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	MAVQGPEETV TQDCLQLIAD SETPTIQKGS YTFVPWLLSF KRGSALEEKE NKILVKETGY FFIYGQVLYT DKTYAMGHLI QRKKVHVFGD ELSLVTLFRC IQNMPETLPN NSCYSAGIAK LEEGDELQLA IPRENAQISL DGDVTFFGAL KLL

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