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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
北京百奥莱博科技有限公司
- 库存:
447
- 级别:
多克隆抗体
- 目录编号:
YT706
- 克隆性:
多克隆
- 保质期:
二年
- 抗体英文名:
Cyclin D1 Rabbit Polyclonal Antibody
- 抗体名:
抗体
- 宿主:
兔
- 适应物种:
人,小鼠,大鼠
- 形态:
液体
- 应用范围:
WB,IHC
- 保存条件:
-20℃冻存,避光
- 规格:
50μl
特别提示:包括兔抗Cyclin D1抗体在内,本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途!
产品名称:兔抗Cyclin D1抗体
英文名称:Cyclin D1 Rabbit Polyclonal Antibody
产品货号:YT706
产品规格:50μl
本品为来源于兔的抗细胞周期蛋白D1(Cyclin D1)的多克隆抗体。
宿主:兔
克隆性:多克隆抗体
用途:WB,IHC
交叉反应性:人,小鼠,大鼠
分子量:36KDa
推荐稀释比例:WB(1:1000),IHC(1:100)
| About this Antibody | |
| Name | Cyclin D1 Rabbit Polyclonal Antibody |
| Category | Polyclonal antibody(pAb); Primary antibody |
| Isotype | IgG |
| Purification | Peptide affinity purified |
| About the Immunogen | |
| Immunogen | This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to N-terminal residues of mouse Cyclin D1. |
| Gene ID | 595 |
| SwissProt | P24385 |
| Synonyms | CCND1;BCL1; D11S287E; PRAD1; U21B31 |
| Category | Cell Cycle / Checkpoint Control |
| Background | Cyclins function as regulators of CDKs (Cyclin-dependent kinase). Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. Cyclin D1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Immunohistochemical staining of cyclin D1 antibodies is used to diagnose mantle cell lymphoma. Cyclin D1 has been found to be overexpressed in breast carcinoma. Its potential use as a biomarker was suggested . |
注意事项:
1. 如果本抗体用于Western blot (WB)、免疫荧光(IF)、免疫细胞化学(ICC)等实验,请注意回收使用过的稀释抗体。回收的抗体通常至少可以重复使用5-10次。稀释后的抗体,包括已经使用过的稀释抗体,请4℃保存。
2. 回收后重复使用的抗体,使用方法同新鲜稀释的抗体。如果在重复使用过程中发现抗体出现轻微混浊现象,可以10,000g离心1-3分钟,取上清用于后续检测。如果回收的抗体出现明显的絮状物或长霉长菌等情况,则可以考虑废弃该抗体。
3. 提供的Western一抗稀释液也可以用于免疫荧光(IF)、免疫组化(IHC)、免疫细胞化学(ICC)等适当用途。如果希望获得最佳的检测效果,请考虑使用上述检测专用的一抗稀释液。
储存条件:-20℃,有效期一年。
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文献和实验CDK Pathway: Cyclin-Dependent Kinases (cdks) and Cyclin-Dependent Kinase Inhibitors
In elucidating a novel cell-cycle pathway or mode of regulation, it will first be necessary to establish that the cell is arrested in a particular stage of the cell cycle following arrest-inducing conditions. This is achieved by staining
【求助】谁有兔抗Paxillin和鼠抗phorsphotyrosine
kelvin12 请问各位同行谁有多余的兔抗Paxillin和鼠抗phorsphotyrosine,能否相赠?谢谢! iammonkey kelvin12战友:你知道paxillin磷酸化的阻断剂是什么吗?正做相关东西,刚接触不太明白! 磷酸化抗体 我公司有现货,具体如下: IBN4001 e-Acetylated Lysine Antibody IBN4006 e
The cyclin/cyclin-dependent kinase (Cdk) complexes and the Cdk inhibitors (CDKI) are crucial regulators of cell cycle progression in all eukaryotic cells. Using rat cardiac myocytes as a model system, this chapter provides a detailed account
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