产品货号:jlcR18234 英文名称 : LEPROTL1 中文名称 :瘦素受体重叠转录基因1抗体 别 名 : HSPC112; Leprotl1; Leptin receptor overlapping transcript-like 1; LERL1_HUMAN; my047; Vps55. 研究领域 :细胞生物 生长因子和激素 细胞膜受体 抗体来源 :Rabbit 克隆类型 :Polyclonal 交叉反应 : Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, Guinea Pig, 产品应用 :ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 :14kDa 细胞定位 :细胞膜 性 状 :Lyophilized or Liquid 浓 度 : 1mg/ml 免 疫 原 :KLH conjugated synthetic peptide derived from human LEPROTL1:81-131/131 亚 型 :IgG 纯化方法 : affinity purified by Protein A 储 存 液 :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 :Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed :PubMed 产品介绍 : Mutation of Ob (Obesity factor), also known as leptin precursor, results in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. The Ob gene product may function as a component of a signaling pathway in adipose tissue that functions to regulate body fat depot size. The leptin receptor, designated Ob-R, has been shown to be a single membrane-spanning receptor that most resembles the gp130 signal transducing component of the IL-6, G-CSF and LIF receptor. LEPROTL1 (Leptin receptor overlapping transcript-like 1) is a 131 amino acid multi-pass membrane protein that is highly homologous to the leptin receptor gene-related protein, Ob-R. LEPROTL1 is widely expressed and contains a JAK binding site. The LEPROTL1 gene is located on chromosome 8, which is made up of nearly 146 million bases and encodes about 800 genes.
Function: Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.
Subcellular Location: Membrane.
Tissue Specificity: Widely expressed, with highest expression in heart, testis, adrenal gland, thymus, and spleen, and lowest expression in lung and skeletal muscle.
Similarity: Belongs to the OB-RGRP/VPS55 family.
SWISS: O95214
Gene ID: 23484
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.