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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
江西江蓝纯生物试剂有限公司
- 库存:
88
- 克隆性:
单克隆
- 保质期:
1年
- 抗体英文名:
GPM6A
- 抗体名:
神经细胞膜糖蛋白M6a抗体
- 适应物种:
人/动物/植物
- 应用范围:
WB,ELISA等
- 浓度:
1mg/ml
- 保存条件:
-20 °
- 规格:
100ul/200ul
| 规格: | 100ul | 产品价格: | ¥1580.0 |
|---|---|---|---|
| 规格: | 200ul | 产品价格: | ¥2480.0 |
英文名称 : GPM6A
中文名称 : 神经细胞膜糖蛋白M6a抗体
别 名 : GPM6A; GPM6A_HUMAN; M6a; M6 a; M6-a; Neuronal membrane glycoprotein M6-a.
研究领域 : 细胞生物 神经生物学
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Dog, Rabbit,
产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 31kDa
细胞定位 : 细胞膜
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human GPM6A:151-250/278 <Extracellular>
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : GPM6A (Glycoprotein M6A) is a Protein Coding gene. GO annotations related to this gene include calcium channel activity. An important paralog of this gene is GPM6B.
Function:
Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.
Subunit:
Interacts with OPRM1
Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, dendritic spine. Cell projection, filopodium. Note=Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons. Localized to the growth cone edge membrane of elongating axons.
Similarity:
Belongs to the myelin proteolipid protein family.
SWISS:
P51674
Gene ID:
2823
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片
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文献和实验酰胆碱和磷脂酰乙醇胺相似,并带有与它们同样的电荷。动物细胞的大多数膜中都有鞘磷脂。某些神经细胞周围的髓鞘含鞘磷脂极丰富。脑苷脂不含磷,也不带电荷,因其极性头基是中性。其特征是含有 1个或更多个糖单位,故也常称糖鞘脂。如脑细胞膜的半乳糖脑苷脂的极性头基是半乳糖;非神经组织膜的葡萄糖脑苷脂的极性头是葡萄糖。还有一些含有 2个、 3个或 4个糖基的更复杂的脑苷脂,存在于细胞膜的外层,是构成细胞表面的重要组分。其中的糖可以是 D-葡萄糖、 D-半乳糖或 N-乙酰基 -D-半乳糖胺。神经节苷脂是最复杂的糖鞘脂,含有
)CD2分子 此分子亦称为LFA-2、Len-5或羊红细胞受体等名称。为55KD单体分子,属Ig基因超家族,亦为穿膜糖蛋白分子。可存在于成熟T细胞及胸腺细胞,亦可发现于NK细胞。 CD2分子是细胞间粘附分子,其配体分子称为白细胞功能相关抗原-3(LFA-3,CD58),为55-70KD糖蛋白分子。可广泛表达于造血细胞和非造血细胞。CD2分子与羊红细胞上LFA-3结合形成花环,称为E-花环,可用鉴定和分离人T细胞。 CD2也是信号传导分子,可使T细胞活化,它不依赖于TCR
(sphingomyelin,SM)在脑和神经细胞膜中特别丰富。以鞘胺醇(sphingoine)为骨架,与一条脂肪酸链组成疏水尾部,亲水头部也含胆碱与磷酸结合。原核细胞、植物中没有鞘磷脂。 (二)、糖脂 是含糖而不含磷酸的脂类,含量约占脂总量的5%以下,在神经细胞膜上糖脂含量较高,约占5-10%。 糖脂也是两性分子,其结构与SM很相似,只是由一个或多个糖残基代替了磷脂酰胆碱而与鞘氨醇的羟基结合。 最简单的糖脂是半乳糖脑苷脂,在髓鞘的多层膜中含量丰富;变化最多、最复杂的糖脂是神经节苷脂,其头部包含一个或几个唾液
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