产品货号 : jlcR7656 英文名称 : ATAD5 中文名称 : 染色体脆弱性相关基因抗体 别 名 : ATPase family AAA domain containing 5; C17orf41; chromosome fragility associated gene 1; FRAG1; Putative uncharacterized protein Fragment. 研究领域 : 细胞生物 染色质和核信号 细胞凋亡 细胞周期蛋白 表观遗传学 抗体来源 : Rabbit 克隆类型 : Polyclonal 交叉反应 : Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, 产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 : 203kDa 细胞定位 : 细胞核 性 状 : Lyophilized or Liquid 浓 度 : 1mg/ml 免 疫 原 : KLH conjugated synthetic peptide derived from human ATAD5:1151-1250/1844 亚 型 : IgG 纯化方法 : affinity purified by Protein A 储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed : PubMed 产品介绍 : ATAD5 is a homolog of a subunit of RFC (replication factor C) and has been shown to be down-regulated in response to replicative stress. ATAD5 may play a role in the surveillance of DNA damage and the cell’s decision to survive or activate apoptosis.
Subunit: "Interacts with RB1 predominantly in G1 phase via its LXCXE motif. Interacts with RAD9A in growing cells. The interaction with RAD9A is reduced after exposure to DNA replication-inhibiting agents.
Subcellular Location: Nucleus.
Similarity: Belongs to the AAA ATPase family.
SWISS: Q96QE3
Gene ID: 79915
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.