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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
江西江蓝纯生物试剂有限公司
- 库存:
185
- 克隆性:
单克隆
- 保质期:
1年
- 抗体英文名:
NPEPPS
- 抗体名:
嘌呤霉素敏感性氨肽酶蛋白抗体
- 适应物种:
人/动物/植物
- 应用范围:
WB,ELISA等
- 浓度:
1mg/ml
- 保存条件:
-20 °
- 规格:
100ul/200ul
| 规格: | 100ul | 产品价格: | ¥1580.0 |
|---|---|---|---|
| 规格: | 200ul | 产品价格: | ¥2480.0 |
英文名称 : NPEPPS
中文名称 : 嘌呤霉素敏感性氨肽酶蛋白抗体
别 名 : PSAP; AAP-S; aminopeptidase puromycin sensitive; Cytosol alanyl aminopeptidase; METALLOPROTEASE 100; METALLOPROTEASE MP100; MP 100; MP100; Npepps; PSA; PSA_HUMAN; Puromycin sensitive aminopeptidase; Puromycin-sensitive aminopeptidase.
研究领域 : 细胞生物 神经生物学 Alzheimer's
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
产品应用 : ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 103kDa
细胞定位 : 细胞浆
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human NPEPPS:201-300/919
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : Puromycin-sensitive aminopeptidase is a 100kDa zinc metallopeptidase which degrades neuropeptides by removing amino acid residues from the amino-terminus. The protein is the most abundant aminopeptidase in the brain, however it is not exclusive to that organ. It is localized primarily in the cytoplasm, and plays a role in the metabolism of neuropeptides in nerve terminals and synaptic clefts. The human PSA gene maps to chromosome 17q 2-32.
Function:
Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Detected in liver, epithelium of renal tubules, epithelium of small and large intestine, gastric epithelial cells, and alveoli of the lung (at protein level).
Similarity:
Belongs to the peptidase M1 family.
SWISS:
P55786
Gene ID:
9520
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片
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文献和实验,使已合成的多肽链不能脱落离核糖体。四环素类抗生素除对菌体70S核糖体有抑制作用外,对人体细胞的80S核糖体也有抑制作用,但对70S核糖体的敏感性更高,故对细菌蛋白质合成抑制作用更强。 3、氯霉素: 属于广谱抗生素。①氯霉素与核糖体上的A位紧密结合,因此阻碍氨基酰tRNA进入A位,②抑制转肽酶活性,使肽链延伸受到影响,菌体蛋白质不能合成,因此有较哟的抑菌作用。 4、嘌呤霉素(Puromycin) 结构与酪氨酰-tRNA相似,从而取代一些氨基酰tRNA进入核糖体的A位
%,特异性98%,ENA法检查甘露聚糖抗体对念珠菌感染的诊断敏感性53%,特异性94%. 4.检查血清中D-阿拉醇或D-阿拉伯醇与L-阿拉伯醇的比值可快速诊断念珠菌病。Yeo等用基因重组的D-阿拉伯醇脱氢酶以酶荧光法定量,发现念珠菌感染者血清中来自菌体的D-阿拉伯醇明显升高,用此法迅速论断新生儿的侵袭性念珠菌病。 Mitsutake等比较了自39名深部念珠菌病患者血液中检出抗原的四种方法。应用斑点印迹法检查其烯醇化酶(Enlase)抗原的阳性率71.8%,特异性100%;应用胶乳凝集检查热敏
链不能脱落离核糖体。四环素类抗生素除对菌体70S核糖体有抑制作用外,对人体细胞的80S核糖体也有抑制作用,但对70S核糖体的敏感性更高,故对细菌蛋白质合成抑制作用更强。 3、氯霉素: 属于广谱抗生素。①氯霉素与核糖体上的A位紧密结合,因此阻碍氨基酰tRNA进入A位,②抑制转肽酶活性,使肽链延伸受到影响,菌体蛋白质不能合成,因此有较哟的抑菌作用。 4、嘌呤霉素(Puromycin) 结构与酪氨酰-tRNA相似,从而取代一些氨基酰tRNA进入核糖体的A位,当延长
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