产品货号:jlcR9736 英文名称:D53/TPD52L1 中文名称:肿瘤蛋白D53抗体 别 名:D53; D54; hD53; hD54; Tpd52l1; TPD52L2 TPD53_HUMAN; Tumor protein D52 like 1; Tumor protein D52 like 2; Tumor protein D52-like 1; Tumor protein D53; Tumor protein D54. 研究领域:肿瘤 细胞生物 免疫学 信号转导 细胞周期蛋白 激酶和磷酸酶 细胞分化 肿瘤细胞生物标志物 抗体来源:Rabbit 克隆类型:Polyclonal 交叉反应: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 产品应用:WB=1:500-2000 ELISA=1:500-1000 IHC-F=1:400-800 IF=1:50-200 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量:22kDa 细胞定位:细胞核 细胞浆 细胞外基质 分泌型蛋白 性 状:Lyophilized or Liquid 浓 度:1mg/ml 免 疫 原:KLH conjugated synthetic peptide derived from human TPD52L1/D53:101-200/204 亚 型:IgG 纯化方法:affinity purified by Protein A 储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed:PubMed 产品介绍background: The cell commits to dividing during the G2/M phase transition, and the timing of mitotic entry is tightly regulated to guarantee correct chromosome segregation. D53, also referred to as tumor protein D52-like 1 (TPD52L1), is a coiled-coil motif-bearing member of the D52 tumor protein family. D53 intereacts with 14-3-3, a negative regulator of the G2/M transition, in breast cancer cells. Expression of D53 is highly upregulated at the G2/M phase transition in breast cancer cell lines, and deregulated expression of this protein can adversely affect the completion of mitosis. D53 may function as a signaling intermediate and/or regulator of vesicle trafficking and cell proliferation.
Subunit: Forms a homodimer or heterodimer with other members of the family.
Similarity: Belongs to the TPD52 family.
SWISS: Q16890
Gene ID: 7164
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.